Immune Cells Feed Breast Cancer Tumors as AI and DNA Testing Reshape Cancer Care
New MSK studies reveal that immune cells secretly feed triple-negative breast cancer, a CXCR2 blocker sensitizes leptomeningeal metastases to radiation, ...
Tag: trastuzumab deruxtecan
Beyond target expression: a modular framework to predict who benefits from antibody–drug conjugates
A Nature Reviews Clinical Oncology Review proposes a modular biomarker framework that moves ADC patient selection beyond semi-quantitative immunohistochemistry by ...
Right-Sizing HER2-Positive Breast Cancer Treatment: New Algorithms Reshape Care Across the Disease Continuum
A new Nature Reviews Clinical Oncology review charts how HER2-targeted therapies, led by trastuzumab deruxtecan, are driving a shift from ...
Real-World Data Show Trastuzumab Deruxtecan Extends Survival in HER2-Low Metastatic Breast Cancer
A real-world cohort of 126 Chinese patients shows trastuzumab deruxtecan delivers a median 9.1 months of progression-free survival in HER2-low ...
Antibody–Drug Conjugates Emerge as Immune Modulators, Not Just Targeted Chemotherapy
A new review argues that antibody–drug conjugates act as immune modulators through immunogenic cell death, Fc-mediated effector functions and tumour ...
Landmark Real-World Study Will Track a Breakthrough Lung Cancer Drug Across China
A new multicenter observational study called RERUN will evaluate the real-world effectiveness and safety of trastuzumab deruxtecan in about 150 ...
Less Surgery, Smarter Drugs: The Trials Rewriting Breast Cancer Care in 2025
Landmark trials from 2024 and 2025 are transforming breast cancer care by safely scaling back surgery while unleashing antibody-drug conjugates, ...
Precision Warheads: How Antibody–Drug Conjugates Are Redefining Lung Cancer Treatment
A comprehensive review details how antibody–drug conjugates targeting TROP2, HER2, c-MET, and other antigens are transforming non-small cell lung cancer ...
New Expert Consensus Maps the Safety Minefield of HER2-Guided Cancer Drugs in Digestive Tumors
A new Chinese expert consensus provides detailed, evidence-graded guidance for managing the hematologic, gastrointestinal, pulmonary, hepatic, neurologic, and ocular side ...
HER2-Low Breast Cancer Mirrors HER2-0 in Metastasis Timing but Confers a Survival Edge
A retrospective study of nearly 1,600 patients finds that HER2-low breast cancer behaves like HER2-0 disease in metastatic timing and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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