T-DXd Plus Osimertinib Shows Benefit in HER2-Overexpressing Resistant Lung Cancer
A multicenter real-world study has reported that combining trastuzumab deruxtecan with osimertinib may offer clinical benefit for patients with HER2-overexpressing ...
Tag: trastuzumab deruxtecan
Rare breast cancer case survives 21 months after leptomeningeal spread
A Taiwanese case report documents 21-month survival after leptomeningeal metastasis in a rare triple-negative breast cancer subtype treated with sacituzumab ...
T-DM1 Shows Limited Activity After T-DXd in HER2-Positive Metastatic Breast Cancer
A single-center study of 21 patients found that trastuzumab emtansine produced no responses and a median progression-free survival of 2.20 ...
First-line trastuzumab deruxtecan extends progression-free survival in HER2-mutant lung cancer
The Phase 3 DESTINY-Lung04 trial reports that first-line single-agent trastuzumab deruxtecan significantly improved progression-free survival and response rates versus pembrolizumab ...
PET Imaging Advances Track Cancer Therapy, Metastases and Dementia Signals
Six ahead-of-print studies in The Journal of Nuclear Medicine report PET tracking of radiolabeled trastuzumab deruxtecan in preclinical tumors, astatine-211 ...
Modeling Study Shows Single-Dose Netupitant Blocks Nausea Receptors Far Longer Than Aprepitant
A pharmacokinetic and pharmacodynamic modeling study finds that single-dose netupitant maintains neurokinin-1 receptor occupancy far longer than aprepitant, suggesting extended ...
Guided missiles of cancer medicine: how antibody-drug conjugates are rewriting targeted therapy
A comprehensive Molecular Cancer review explains how antibody-drug conjugates deliver lethal payloads to tumors, why resistance emerges, and which next-generation ...
Antibody-Drug Conjugate Shows Striking First-Line Results in HER2-Driven Lung Cancer
A multicenter real-world study found that first-line trastuzumab deruxtecan doubled progression-free survival compared with chemotherapy in HER2-altered advanced NSCLC, while ...
Immune Cells Feed Breast Cancer Tumors as AI and DNA Testing Reshape Cancer Care
New MSK studies reveal that immune cells secretly feed triple-negative breast cancer, a CXCR2 blocker sensitizes leptomeningeal metastases to radiation, ...
Beyond target expression: a modular framework to predict who benefits from antibody–drug conjugates
A Nature Reviews Clinical Oncology Review proposes a modular biomarker framework that moves ADC patient selection beyond semi-quantitative immunohistochemistry by ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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