CUL3 mutations reshape NRF2 control in TP53-mutant lung cancer
A multi-cohort genomic and molecular dynamics study links CUL3 mutations to TP53-associated NRF2 dysregulation in EGFR-driven non-small cell lung cancer ...
Tag: TCGA
SIX1 and TEAD1 Team Up to Drive Colorectal Tumor Growth via CTGF
A new study shows the transcription factors SIX1 and TEAD1 synergistically promote colorectal tumor growth by directly co-regulating the CTGF ...
Oxidative Stress Gene Signature Flags Prostate Cancer Recurrence Risk
A LASSO-based risk score built from oxidative stress-related genes predicts biochemical recurrence in prostate cancer, with LAMP5 knockdown reducing PC3 ...
Long non-coding RNA TMPO-AS1 flags poor outcomes in lung adenocarcinoma
A multi-database bioinformatics study identifies the long non-coding RNA TMPO-AS1 as overexpressed in lung adenocarcinoma and linked to poor survival ...
DNA Repair Protein RPA Emerges as Poor-Prognosis Marker in Liver Cancer
A computational pan-cancer analysis links overexpression of the RPA gene family to worse survival and an immunosuppressive tumor microenvironment in ...
BUB1 kinase inhibition slows endometrial cancer growth in lab study
A multi-omics and in vitro study finds BUB1 overexpressed in endometrial carcinoma, linked to poor survival, and suppressible by the ...
TTC39B emerges as a pan-cancer prognostic marker suppressing renal cancer cell growth
A pan-cancer analysis links TTC39B expression to prognosis and tumor immunity across 33 cancer types, with experiments showing the gene ...
Pan-Cancer Analysis Maps PTPN3’s Contrasting Roles Across Tumors
A multi-platform pan-cancer analysis finds PTPN3 shows cancer-type-dependent differences in expression, survival associations, genomic alterations, phosphorylation and stromal correlations.
Computational Study Maps Resveratrol’s Potential Protein Targets in Lung Squamous Cell Carcinoma
A computational study combining database mining, network analysis and molecular docking identifies TP53, AKT1, IL6 and CCND1 as potential resveratrol ...
SWI/SNF Chromatin Complex Gene Expression Mapped Across 33 Cancer Types
A pan-cancer analysis of about 11,000 TCGA samples maps the expression of all 29 SWI/SNF chromatin remodeling genes across 33 ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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