Lung Cancer Outsmarts KRAS Drugs Through Two Distinct Escape Routes
MIT researchers have found that lung adenocarcinomas can evade KRAS inhibitors either by amplifying the KRAS gene or by transforming ...
Tag: Targeted therapy
Mutational Map of Gallbladder Cancer Reveals New Paths to Precision Therapy
A new review maps the recurrent mutations and signaling crosstalk driving gallbladder cancer, identifying ERBB2 and KRAS as hub targets ...
Rare Aggressive Sarcoma Shows Surprising Sensitivity to Targeted Small Molecules in New Lab Study
A new laboratory study shows that desmoplastic small round cell tumor cells are highly vulnerable to histone deacetylase inhibitors, p53 ...
Who Needs Intensive Lung Cancer Therapy? New Algorithm Aims to Match EGFR-Mutant Patients to the Right First Treatment
A new review proposes a risk-adapted algorithm to help clinicians decide which patients with advanced EGFR-mutant lung cancer need intensive ...
PI3K/AKT/mTOR Pathway Emerges as Central Target in Gastrointestinal Cancers
A comprehensive review finds that the PI3K/AKT/mTOR signaling axis drives progression and therapy resistance in gastrointestinal cancers, but clinical success ...
International Experts Set the Rules for Precision Testing in Bile Duct Cancer
An international expert consensus published in Clinical Cancer Bulletin establishes fifteen recommendations for molecular biomarker testing in intrahepatic cholangiocarcinoma, defining ...
Nebulized Designer Exosomes Deliver Pirfenidone Directly to Fibrotic Lungs
Researchers engineered anti-FAP-targeted exosomes loaded with pirfenidone and showed that nebulized delivery outperforms intravenous injection in treating pulmonary fibrosis in ...
Adding an Antibody to Venetoclax Deepens Responses in Hard-to-Treat Lymphoma
A French retrospective study of 46 patients with relapsed or refractory Waldenström macroglobulinemia found that venetoclax combined with an anti-CD20 ...
Hidden RNA Tags May Steer Lung Cancer Growth, Treatment Response, and Survival
A sweeping review reveals how the RNA modification N6-methyladenosine orchestrates lung cancer progression, drug resistance, immunotherapy response, and survival prediction.
Mushroom Compound Pachymic Acid Supercharges Lenvatinib Against Liver Cancer by Starving Tumors of Sugar
A new study shows that pachymic acid, a compound from the medicinal mushroom Poria cocos, synergizes with lenvatinib against hepatocellular ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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