Tag: targeted protein degradation

A Baylor College of Medicine-led team combined high-throughput proteomics and AI-based structural prediction to discover and optimize a new class ...

A 58-article special issue of Molecular Diversity shows how synthetic chemistry, protein degraders, natural products, and AI-driven screening are converging ...

Researchers have built a scalable transcriptomic screening platform that uses gene expression signatures and CRBN knockout cell models to systematically ...

Scientists report that TRI-611, a brain-penetrant molecular glue degrader, eliminates ALK fusion proteins and drives tumor regressions in preclinical models ...

Scientists created CJ1, a hydrophobic tagging molecule that selectively destroys the DAPK1 kinase via the proteasome, reducing tau phosphorylation, neurofibrillary ...

A new comprehensive review in Discover Chemistry details how PROTACs have evolved from a mechanistic concept into clinically advanced degraders ...

A new review in Molecular Diversity charts the rapid rise of dual PROTACs, single molecules engineered to destroy two disease-driving ...

The field of targeted protein degradation, one of the most rapidly evolving areas in modern pharmacology, has just taken a ...

Dana-Farber Cancer Institute researchers have developed a systematic platform for discovering molecular glue degraders, a class of drug-like compounds that ...

In a groundbreaking advancement that could redefine the paradigms of targeted protein degradation, a team of researchers has unveiled a ...