Small Molecule Strategy Degrades Many Disease Proteins at Once in Cell Models
A new small molecule strategy activates a stress-responsive E3 ligase to degrade multiple disease-causing proteins at once, restoring mitochondrial function ...
Tag: targeted protein degradation
Modified PROTACs Show Stronger BRD4 Degradation in KSHV-Infected Cells
Chemically modified BRD4 degraders MZ-1-ME and SIM-1-ME showed enhanced protein degradation and growth inhibition in a KSHV-infected endothelial cell model ...
Targeted Protein Degraders Offer a New Route Past Breast Cancer Drug Resistance
A new review outlines translational frameworks for using targeted protein degradation to eliminate the proteins that drive acquired resistance in ...
Ubiquitination emerges as a central lever in diabetic heart disease
A Cell Division review maps how ubiquitination links diabetic stress to protein turnover, mitochondrial function, inflammation, and cell death in ...
mRNA-encoded antibodies show early clinical promise in cancer therapy
A Journal of Translational Medicine review outlines how mRNA-encoded antibodies, bispecific constructs, and transient CAR expression could overcome the manufacturing ...
Targeted Lysosomal Degradation: From Receptor Hijacking to Endolysosomal Routing
A review identifies post-endocytic routing as the decisive step in targeted lysosomal degradation and proposes a five-tier framework for verifying ...
AI-designed molecular glue degrader ISM9546 targets VAV1 for autoimmune disease treatment
The nomination of ISM9546 arrives at a moment when the field of targeted protein degradation is moving well beyond its ...
Next-Generation CRBN Modulators Show Promise Against IMiD Resistance in PROTAC Therapy
A new computational study suggests that next-generation CRBN E3 ligase modulators, particularly CC-885, may hold the key to overcoming mutation-driven ...
Scientists Build Screening Toolkit to Find Bait Ligands for Antibacterial Protein Degradation Drugs
Researchers have developed fluorescence polarization and thermal shift screening methods to identify small-molecule bait ligands for the bacterial ClpC N-terminal ...
How HIV-1’s Vpr Protein Hijacks a Human Degradation Machine to Destroy Diverse Targets
New cryo-EM structures reveal how the HIV-1 protein Vpr reshapes the human CRL4(VprBP) E3 ligase to degrade host substrates of ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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