Tag: structure-activity relationship

A comprehensive review of naloxone's chemistry, receptor pharmacology and clinical pharmacokinetics explains why the lifesaving opioid antagonist acts so quickly ...

A new review argues that pyrazolopyridine derivatives show therapeutic potential against Alzheimer's disease and distils the structural rules for designing ...

A new bibliometric and pharmacological review of 423 Scopus-indexed publications maps four decades of anticancer quinazoline research, revealing a 2018 ...

A structurally complex pectic polysaccharide from Typha angustifolia pollen promoted maturation of mouse bone marrow-derived dendritic cells and enhanced antigen-specific ...

A systematic review of 2020–2025 research highlights piperazine derivatives with potent activity against bacteria, tuberculosis, breast cancer cells and Zika ...

Silver nanoparticles shaped as pentagonal nanorods killed colon cancer cells more effectively than similarly sized decahedral particles, according to a ...

Researchers in India synthesized five new piperidin-1-yl-phenyl-acetamide derivatives and found that the 2,5-dimethyl compound AS-5 showed the strongest acetylcholinesterase inhibition, ...

A newly synthesized bis-coumarinyl methane derivative, 14e, inhibits tyrosinase more potently than kojic acid in laboratory and computational studies.

Newly synthesized fluorinated azabicyclo–benzohydrazone compounds showed stronger-than-standard antibacterial and antifungal activity in laboratory assays, with halogen substitution emerging as the ...

A novel series of benzimidazole-based hydrazone derivatives shows significant gastroprotective activity in rats, with compound SH1 achieving efficacy comparable to ...