Persister cells hiding in minimal residual disease drive cancer relapse
A new review outlines how drug-tolerant persister cells hidden within minimal residual disease drive cancer relapse and how pathway inhibitors, ...
Tag: single-cell sequencing
Scientists Map Two Distinct T Cell Exhaustion Programs Driving AML Relapse Before and After Transplant
Single-cell sequencing reveals that self-derived and donor-derived exhausted T cells in acute myeloid leukemia run on different transcriptional programs, with ...
Dual autoencoder framework sharpens single-cell clustering accuracy
A new deep clustering method, scDAEC, combines two autoencoders and multi-head attention to untangle noisy single-cell RNA sequencing data, outperforming ...
Scientists Uncover Four Genes That May Explain Why Psoriasis and Depression Strike Together
An integrated multi-omics study identifies four shared genes and folic acid as a potential therapeutic link between psoriasis and depression.
The Brain’s Silent Partnership: How Astrocytes and Microglia Talk From Birth to Disease
A new review reveals that astrocytes and microglia engage in lifelong bidirectional communication that shapes brain development, maintains homeostasis, and ...
Genomic Imprinting’s Hidden Role in Cancer: New Methods Tackle Loss of Imprinting
A new review highlights how loss of imprinting drives tumour growth and why emerging single-cell, spatial, and long-read methods may ...
Scientists uncover how tobacco rewires head and neck cancer metabolism through a single mucin molecule
New research reveals that tobacco carcinogens lift a GATA4-mediated brake on the mucin MUC5B, driving fatty acid metabolism and immune ...
Single-Cell Sequencing Reveals Mitochondrial DNA Damage in Vulnerable Parkinson’s Neurons
For the first time, researchers have sequenced mitochondrial DNA from individual vulnerable brainstem neurons in Parkinson's disease, revealing extensive deletions ...
Tumors Are Not Sterile: How Microbes Living Inside Cancers Reshape Immunity and Immunotherapy
A new review in Molecular Cancer argues that microbes living inside tumors dynamically reprogram immunity and can determine whether patients ...
Blood Test Clue: Immune Cells That Betray Early Lung Cancer Before It Strikes
Researchers have discovered a clonally coordinated network of suppressive regulatory T cells that spans the blood, lymph nodes and airways ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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