Lymphatic Vessels Emerge as Hidden Conductors of the Developing Heart’s Growth
Northwestern scientists have discovered that cardiac lymphatic vessels secrete the protein Reelin to maintain the epicardium and fibroblasts, revealing a ...
Tag: Single-Cell RNA Sequencing
New Topic Model Traces Cell Identity Back to Regulatory Paths in Single-Cell Data
Researchers have developed RegPathTopic, a deterministic topic-modeling framework that builds traceable regulatory vocabularies from transcription factor-target graphs and benchmarks them ...
Liver Cancer Gene GNG4 Found to Build Walls That Keep Immune Cells Out of Tumors
New research links the gene GNG4 in malignant liver cells to tumor immune exclusion and reduced CD8-positive T cell infiltration ...
Bioprinted Human Vascular Organoid Sheets Restore Blood Flow in Ischemic Limbs
Researchers have 3D bioprinted human vascular organoid sheets from stem cell-derived endothelial and smooth muscle cells that integrate with host ...
ATP-Sensing Receptor P2RX4 Emerges as a Molecular Window Into Triple-Negative Breast Cancer’s Immune Landscape
A multi-omics study links the ATP-gated receptor P2RX4, expressed mainly by tumor cells, to macrophage marker CD163 and hypoxia signatures ...
Graph Transformer Model Aims to Sharpen RNA Velocity Predictions in Single-Cell Genomics
Researchers have developed GTVelo, a graph transformer-based neural ordinary differential equation model that improves RNA velocity inference by capturing long-range ...
Aging Rewires Neutrophils Across the Body, Single-Cell Map Reveals
A single-cell atlas of eight mouse organs shows that aging expands immature, inflammatory neutrophil states that may help drive senescence ...
Lysosome Gene Signature Offers New Prognostic Tool for Lung Cancer
Researchers have built a 13-gene lysosome-related signature that predicts survival, immune landscape, and drug responses in lung adenocarcinoma patients.
Dogs’ Insulin-Secreting Tumors Reveal Two Hidden Cancer Cell Types in First-of-Its-Kind Study
The first single-cell RNA sequencing study of naturally occurring insulinoma in any species reveals two distinct insulin-expressing cancer cell populations, ...
Immune Receptor LAIR1 Slows Leukemia Cell Growth by Triggering Cell Cycle Arrest and Apoptosis
New research shows that the immune inhibitory receptor LAIR1 is downregulated in chronic lymphocytic leukemia, and that restoring its expression ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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