FBXO28 ubiquitinates BRD4 to fuel lung cancer cell malignancy
A study in non-small cell lung cancer models found that FBXO28 promotes proliferation, migration and invasion by ubiquitinating BRD4 and ...
Tag: RNA polymerase II
Low Oxygen Helps Early Embryos Switch On Their Genes, Mouse Study Finds
A new mouse study shows that hypoxic culture enhances zygotic genome activation by increasing H3K4me3 at zygotic gene promoters and ...
Super Elongation Complex Found to Switch On Genes That Transform Cell Identity
New research shows that the Super Elongation Complex drives both stem cell reprogramming and neural differentiation by releasing paused RNA ...
Gene Activity Comes in Bursts: Epigenetics Reshapes the Picture of Transcriptional Noise
A new review argues that transcription occurs in multi-scale bursts shaped by DNA methylation, histone variants, modifications and enhancer looping, ...
Cryo-EM Reveals How RNA Polymerase II Remodels and Stalls at Cisplatin DNA Crosslinks
Cryo-electron microscopy captures RNA polymerase II remodeling cisplatin-induced DNA interstrand crosslinks into a novel conformation that blocks the active site, ...
African swine fever virus reshapes host genome architecture within hours of infection
New research shows that African swine fever virus extensively reorganizes host chromatin architecture and RNA polymerase II activity within hours ...
Cryo-EM Reveals the Dynamic Machinery That Switches Genes On
A new Nature Reviews Molecular Cell Biology review synthesizes cryo-EM structures showing how TFIID, Mediator, and the +1 nucleosome orchestrate ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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