Gut Microbe Bile Acid Isoallo-LCA Eases Acute Liver Transplant Rejection in Mice via NR4A1/FOXP3 Pathway
A gut microbial bile acid, isoallolithocholic acid, prolonged survival and reduced rejection injury in a mouse liver transplant model by ...
Tag: regulatory T cells
Dead Microbes, Living Benefits: How Postbiotics and Parabiotics Rewire Immunity
A narrative review of eleven studies finds that non-viable postbiotics and parabiotics modulate innate and adaptive immunity through defined receptor ...
Unstable Regulatory T Cells Weaken the Blood–Brain Barrier After Surgery
A study in Cell Death Discovery links perioperative destabilization of regulatory T cells to blood–brain barrier disruption through a β-catenin–tight ...
Diet and gut microbes drive fragile T cells behind immunotherapy side effects
University of Pittsburgh researchers created a diet-based mouse model showing that fragile regulatory T cells, shaped by a Western-style diet ...
Early-onset colorectal cancer shows distinct immune-cell spatial patterns
A single-cell spatial analysis found similar overall immune-cell abundance but different local organization of regulatory and helper T-cell populations in ...
SLC5A12 Marks and Supports an Invasive State in HNSCC
SLC5A12 marked an invasive HNSCC state, and experimental knockdown reduced tumor-cell behaviors and xenograft growth in preclinical models.
Immune and proliferative programs distinguish anti-PD-1-responsive endometrial cancer
An exploratory multi-omics analysis links regulatory T-cell and proliferation programs to anti-PD-1 response in endometrial cancer, but the treatment comparison ...
JAK-STAT signaling: a key mechanism of immune microenvironment remodeling in breast cancer and novel strategies for targeted therapy
A 2026 review finds that JAK-STAT signaling suppresses antitumor immunity in breast cancer, but mixed clinical trial results expose challenges ...
First DS1025 dose administered in international Phase 1 solid-tumor trial
Kansai Medical University Hospital gave the first worldwide dose of investigational CD25-directed antibody drug conjugate DS1025 in a global Phase ...
Syngeneic mouse study links CNS lymphoma location to broader immune dysfunction
A controlled syngeneic mouse study found that intracranial A20 B-cell lymphoma had stronger T-cell exhaustion, regulatory-cell expansion and dendritic-cell immunoregulation ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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