CYP17A1 Mutations Linked to Steroid Defects in Polycystic Ovary Syndrome Study
An in silico and genotyping study identified 22 pathogenic CYP17A1 mutations and modeled how two heme-binding domain variants may impair ...
Tag: Precision medicine
AI-Designed 3D-Printed Hydrogels Move Toward Repairing Skin and Bone
A new review maps how artificial intelligence is reshaping 3D-printed hydrogel scaffolds for skin and bone regeneration, while flagging the ...
Mitochondrial dysfunction emerges as a shared thread across neurological disease
A new review in Nature Reviews Neurology outlines how mitochondrial biomarkers spanning fluid, genetic, multi-omics and imaging domains could aid ...
Can Genes and Gut Microbes Predict Who Responds to Semaglutide for Liver Disease?
A new review builds an evidence-tiered framework for predicting GLP-1 therapy response in fatty liver disease using host genotype and ...
Precision Medicine in Schizophrenia: Systematic Review of Biomarkers in African Populations
A systematic review of twenty-eight studies across seven African countries synthesizes evidence on blood-based and genetic biomarkers for precision medicine ...
Antibody-Drug Conjugates Extend Survival in Triple-Negative Breast Cancer, Meta-Analysis Finds
A systematic review and meta-analysis of six studies covering 2,479 patients found that antibody-drug conjugates significantly improved progression-free and overall ...
Why Almost No Machine Learning Models Ever Reach the Hospital Bedside
An editorial in Frontiers in Medicine argues that the vast majority of clinical machine-learning models never reach patients, with fewer ...
Exome and Array Data Combined Rival Whole-Genome Sequencing for Most Pharmacogenes
Combining whole-exome sequencing with imputed genotyping array data matched whole-genome sequencing results for 25 of 33 pharmacogenes in UK Biobank ...
Genomics Moves From Variant Discovery to Precision Diagnosis Across Rare and Common Disease
A sweeping editorial on a 2024–2025 research collection describes how long-read sequencing, newborn screening, population genomics, and functional studies are ...
First Placebo-Controlled Trial Will Test Prednisone for Drug-Induced Liver Injury
The DILICORT trial, the first randomized double-blind placebo-controlled study of prednisone in acute idiosyncratic drug-induced liver injury, will enroll sixty ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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