Computational Study Models Tazemetostat Binding in Thyroid Cancer
A computational study in Clinical Epigenetics evaluates tazemetostat's predicted binding to five hub targets in ARID1A-deficient anaplastic thyroid cancer, highlighting ...
Tag: polypharmacology
Biological fingerprints beat chemical structure in predicting drug-induced steatosis
Machine-learning models built from protein-target and pathway fingerprints outperform chemical structure models in predicting drug-induced fatty liver, a new study ...
Ayurvedic phytochemicals offer a multi-target route against antimicrobial resistance
A preclinical review identifies Ayurvedic phytochemicals as possible multi-target antibiotic adjuncts that could disrupt biofilms and resistance machinery, but safety, ...
Plant Compounds Emerge as Multitarget Leads Against Alzheimer’s Disease in Virtual Screen
A computational screen of 2,847 plant compounds against ten Alzheimer's-related proteins identified 36 multitarget phytochemicals with stable binding and literature-backed ...
Computers Hunt Bacteria’s Weak Spots: New Multi-Target Compounds Show Promise Against Staphylococcus aureus
A structure-based screening campaign has identified compounds that inhibit multiple essential Staphylococcus aureus enzymes, with two candidates showing potent antibacterial ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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