Genes May Decide How Well Your Diabetes Drugs Work, Review Finds
A new integrative review synthesizes 31 human studies showing how transporter, enzyme and target gene variants shape individual responses to ...
Tag: polygenic risk scores
Genetic Risk for PTSD May Depend on the Type of Trauma Experienced
A study of more than 144,000 people shows that genetic vulnerability to PTSD varies with the type of trauma experienced, ...
Africa’s genetic diversity could transform global mental health research
A major new review argues that Africa's unmatched genetic diversity, combined with rising mental health needs and growing continental research ...
Cleft palate genetics study finds no common variant link to neurodevelopmental risk
A large genomic study of children with cleft lip and/or palate finds that common genetic variants do not explain the ...
Hidden Genetic Threads Link Cancers Through Shared Regions and Pathways
A new PLOS Genetics study shows that shared genetic susceptibility across cancers is modest genome-wide but becomes structured and biologically ...
New Sparse Regression Method Tames Biobank-Scale Genetic Data for Risk Prediction
Researchers have adapted a two-stage sparse regression method called uniLasso to the UK Biobank, producing polygenic risk scores that match ...
Blood Proteins Predict Diabetes and Heart Disease Years Before Symptoms in Obesity
Researchers built proteomic risk scores from nearly 3,000 blood proteins that predict type 2 diabetes, hypertension, and hyperlipidemia years in ...
Massive Study Aims to Decode the Biology of Aggression Across Mental Disorders
A German consortium has launched a 12-year, 1,100-participant longitudinal study to identify neurobiological biosignatures of aggression that cut across psychiatric ...
Diverse Biobank Data Sharpen Genetic Risk Prediction Where It Matters Most
A new Nature Genetics study shows that the diversity of the All of Us Research Program improves polygenic risk score ...
New Tool Treats Genetic Ancestry as a Continuum to Sharpen Disease Risk Prediction for All Populations
A new method called SPLENDID models genetic ancestry as a continuum rather than discrete labels, significantly improving polygenic risk score ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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