Staphylococcal Protein Reprograms Liver Tumor Macrophages to Boost Immunotherapy
A bacterial protein called LukS-PV reprograms immunosuppressive macrophages in liver cancer by targeting the human C5aR1 receptor, restoring CD8-positive T-cell ...
Tag: PI3K-AKT signaling
Fgl-1 Emerges as an Oncogenic Driver Fueling Endometrial Cancer Through PI3K/AKT Signaling
New research shows that fibrinogen-like protein 1 is overexpressed in endometrial adenocarcinoma and drives tumor growth, migration and invasion by ...
Cancer Cells Defy Quiescence Doctrine as MYC Drives a Proliferative Chemoresistance Program
A sweeping integrated genomics study reveals that chemotherapy-resistant tumors across multiple cancer types share a hyperproliferative, MYC-driven state, identifying the ...
Goldilocks Nerve Conduit Finds the Sweet Spot Between Guidance and Space
Researchers have identified an optimal 5 to 10 percent filling density for micropatterned nerve conduits that balances topographical guidance with ...
Cholesterol Enzyme DHCR24 Emerges as Driver and Biomarker of Endometrial Cancer
New research identifies the cholesterol synthesis enzyme DHCR24 as a driver of endometrial carcinoma progression and a potential prognostic biomarker ...
TET2 Emerges as Genetic Switch Driving Inflammatory Monocytes in Asthma
A new study identifies TET2 as an m6A-regulated gene that drives inflammatory monocyte activation in asthma through ALKBH5-mediated RNA demethylation ...
Cinnamon Compound Shields Ovarian Cells From Hormone-Driven Damage in PCOS Model
New laboratory research shows that cinnamaldehyde, the main bioactive compound in cinnamon, protects human granulosa cells from androgen-induced inflammation and ...
Tumor Vesicles Loaded with SPP1 Rewire Fibroblasts to Shield Lung Cancer from Immunity
New research shows that lung adenocarcinoma cells package the protein SPP1 into extracellular vesicles to reprogram fibroblasts into an MMP11-positive ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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