Exome and Array Data Combined Rival Whole-Genome Sequencing for Most Pharmacogenes
Combining whole-exome sequencing with imputed genotyping array data matched whole-genome sequencing results for 25 of 33 pharmacogenes in UK Biobank ...
Tag: pharmacogenomics
Molecular obesity therapies advance, but precision prescribing remains largely unproven
A 2026 review finds that multi-agonist obesity drugs can produce substantial weight loss, but biomarker and pharmacogenomic tools are not ...
SRPK1 shows tumour-specific associations with survival and predicted chemotherapy response
A retrospective multi-omics study associated SRPK1 expression with opposite survival patterns and different predicted chemotherapy responses in breast, colon and ...
Large Language Models Could Help Detect Pharmacogenomic Phenoconversion
A 2026 perspective proposes that large language models could integrate genetic and clinical records to identify possible pharmacogenomic phenoconversion, while ...
Model finds CYP2C19-guided DAPT cost-effective after PCI
A 40-year NHS cost-effectiveness model estimated that CYP2C19-guided dual antiplatelet therapy after PCI was likely cost-effective for STEMI and UA/NSTEMI ...
The skin as an early warning system: how drug rashes reveal systemic toxicity before lab tests
A comprehensive review argues that drug-induced skin phenotypes can act as early, bedside-visible risk signals of systemic toxicity, identifying specific ...
Inflammation Gene Variant May Shape Survival After Rectal Cancer Therapy Choice
An exploratory analysis of a randomized trial in locally advanced rectal cancer found that an IL1B gene variant was linked ...
Genomic era reshapes how biomarkers are discovered and interpreted
A new Frontiers editorial and eight accompanying studies show how genomic and epigenomic variation is reshaping biomarker discovery, interpretation and ...
GLIS3 Gene Variants Point Diabetes Care Toward Genotype-Guided Therapy
A new review argues that diabetes care must move beyond standardized protocols toward genotype-guided therapy, spotlighting the GLIS3 gene and ...
Hidden Drug Metabolism Shifts May Drive Rural Pain Care Inequities in Older Adults
Researchers propose that unrecognized drug-drug-gene interactions known as phenoconversion contribute to pain treatment failures and harm in rural older adults, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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