Pharmaceutical Chemistry

Physiologically linked systems enhance preclinical drug testing, say Harvard-Tel Aviv University researchers The U.S. Food and Drug Administration (FDA) approves only 13.8% of all tested drugs, and these numbers are even lower in "orphan"…

Fluidically-linked systems of multiple human Organ Chips that quantitatively predict drug pharmacokinetics may offer alternatives to some animal testsCredit: Wyss Institute at Harvard University (BOSTON) -- Drug development is an…

Credit: Newcastle University, UK The damage visible and infrared light can do to our skin has been revealed for the first time in new research by scientists at Newcastle University, UK. The detrimental effects of exposure to the…

Credit: University of Adelaide. The results of the B Part of It study - the largest meningococcal B herd immunity study ever conducted - are published today in the New England Journal of Medicine. The results have implications for all…

Credit: Tokyo Tech The growing knowledge about cancer biology has enhanced the development of many therapeutic strategies that involve selective targeting and killing of cancer cells. One such therapeutic option is boron neutron capture…

With 48 drugs approved by the U.S. Food and Drug Administration (FDA), 2019 was another highly productive year for the pharmaceutical industry. The new medicines include treatments for various cancers, sickle cell disease, migraines and…

After years of research on cell surface receptors called Frizzleds, researchers at Karolinska Institutet in Sweden provide the proof-of-principle that these receptors are druggable by small molecules. The results, which are published in…

A study testing thousands of medicines in hundreds of cancer cell lines in the lab uncovers new tricks for many old drugsCredit: Scott Sassone, Broad Institute Drugs for diabetes, inflammation, alcoholism -- and even for treating arthritis…

Credit: Karolinska Universitetssjukhuset A common and inexpensive drug may be used to counteract treatment resistance in patients with acute myeloid leukemia (AML), one of the most common forms of blood cancer. This is the conclusion…

The work also has implications for speeding drug developmentCredit: University of Houston The process of crystallization is central to drug development, petrochemical processing and other industrial actions, but scientists say they…