Pharmaceutical Chemistry

Columbus, OH, April 2, 2020 - CAS, a division of the American Chemical Society specializing in scientific information solutions, is partnering with research and technology organizations worldwide to tackle the complex challenges presented…

Credit: Haifa Shen, Houston Methodist HOUSTON-(April 1, 2020)-We've all been warned about the dangers of triglycerides, the fat stored in your blood. But what if that unhealthy fat could effectively transport oral medication to…

Fast communication between our brain cells - or neurotransmission as it is called - is hugely important for our brain to work properly. Some of the messengers involved in this form of communication are neuropeptides, which are chemicals…

A team of researchers of the University of Trento focused on a new molecular mechanism that works like a 'switch'Credit: ©Alberto Inga, UniTrento There is an ongoing battle between cancer cells and p53, the protein known as 'the…

Monoclonal antibody effective for the full spectrum of homozygous familial hypercholesterolemia The investigational drug evinacumab reduced low-density lipoprotein (LDL) cholesterol to near-normal levels among patients with a rare…

Finding driven by reduced risk of major bleeding in monotherapy group Patients with acute coronary syndrome (ACS) who stopped taking aspirin three months after the insertion of a coronary stent and then took the anti-platelet medication…

No increase in bleeding, heart attack or stroke in TWILIGHT trial subanalysis Patients with diabetes who stopped taking aspirin three months after the insertion of a coronary stent and then took the anti-platelet medication ticagrelor…

TWILIGHT subanalysis finds benefit for subgroup of high-risk patients Patients with complex heart disease who stopped taking aspirin three months after the insertion of one or more coronary stents and then took the anti-platelet medication…

No serious adverse effects seen after three months of follow-up Three months after undergoing renal denervation (RDN)--a procedure that delivers energy to overactive nerves leading to the kidney to decrease their activity--patients with…

Subgroup analysis suggests concomitant use of clopidogrel may not play role after PAD revascularizations The results of VOYAGER PAD found that people with peripheral artery disease (PAD) who took the blood thinner rivaroxaban with aspirin…

No increase in the risk of major bleeding seen, including for gastrointestinal cancers For people with cancer, the oral blood thinner apixaban is at least as effective as dalteparin, a low molecular weight heparin given by injection, in…

No survival differences seen in randomized, placebo-controlled trial Among patients who had an out-of-hospital cardiac arrest, intravenous sodium nitrite given by paramedics during resuscitation did not significantly improve their chances…

Credit: (Picture: Scigraphix) Strong painkillers are very important in the management of patients with cancer and heart attack or requiring surgery. They extert their effect by binding to so-called opioid receptors in the body. These…

Study by the Universities of Bonn and Ulm investigates how a cellular mechanism can be used for other purposesCredit: © Photo: Barbara Frommann/Uni Bonn An international team of researchers led by the Universities of Bonn and Ulm has…

When people take medications, these drugs and their metabolites can be excreted and make their way to wastewater treatment plants. From there, the compounds can end up in waterways. Wastewater from pharmaceutical companies could start off…

The article by Dr. Kishor Wasan is published in Current Pharmaceutical Design, 2020 The Wasan Laboratory in the Faculty of Pharmaceutical Sciences at the University of British Columbia in partnership with iCo Therapeutics Inc. (Vancouver…

Credit: Centers for Disease Control and Prevention New Orleans, LA - James Diaz, MD, MHA, MPH & TM, Dr PH, Professor and Head of Environmental Health Sciences at LSU Health New Orleans School of Public Health, has proposed a possible…

About one in five Danes are affected by depression at some point in their lives. The severe depressions may be treated with the so-called 'tricyclic antidepressants', an antidepressant drug that is more effective than the drugs used for…

In addition, the review found no consistent evidence that cannabidiol (CBD) moderates the effects of tetrahydrocannabinol (THC - the psychoactive component of cannabis) in healthy volunteers In addition, the review found no consistent…

Credit: iQ Group Global A drug candidate has been found in preclinical trials to stop tumor growth entirely, deliver more cancer-busting power than many commonly used chemotherapy drugs and do so with fewer toxic side effects and more…