Pharmaceutical Chemistry

Treated mice with triple-negative breast cancer lived 150% longer EVANSTON, Ill. -- A new immunotherapy developed by researchers at Northwestern University dramatically extends the survival time of mice with triple negative breast cancer,…

Credit: J. Wollenhaupt/HZB For drugs to be effective, they usually have to dock to proteins in the organism. Like a key in a lock, part of the drug molecule must fit into recesses or cavities of the target protein. For several…

Purdue partners with V Foundation for Cancer Research and the Walther Cancer Foundation, in collaboration with Indiana University School of Medicine, to develop promising new technologyCredit: Purdue University/Sandro Matosevic WEST…

University of Huddersfield researchers find that the benefits of inhalers for asthma sufferers outweigh the risks of contracting coronavirus, following concerns raised after WHO warned that steroids could reduce immunity The benefits of…

Pancreatic cancer carries a poor prognosis, and it often goes undetected until advanced stages. A new BJS (British Journal of Surgery) study indicates that a certain cocktail of chemotherapy drugs may be a safe and effective treatment…

Credit: Arthritis & Rheumatology In a clinical trial of patients with rheumatoid arthritis, treatment with a drug called upadacitinib provided greater benefits than methotrexate, the most commonly used initial therapy for…

UD engineers uncover role of surface diffusion in protein transport, which could aid biopharmaceutical processingCredit: Photo courtesy of Ohnmar Khanal, Vijesh Kumar and Abraham Lenhoff Many of the most promising medicines under…

What The Study Did: How the prescription of hydroxychloroquine and chloroquine to outpatients has changed in the United States during the COVID-19 pandemic is examined in this study. Authors: Daniel S. Budnitz, M.D., M.P.H., of the…

Credit: Susan Daniel/Cornell University Researchers have developed a human cell 'membrane on a chip' that allows continuous monitoring of how drugs and infectious agents interact with our cells, and may soon be used to test potential…

Experiments in mice have shown early success in vaccinating them against potentially deadly bacterial infections, such as methicillin-resistant Staphylococcal aureus, or MRSA, the strain resistant to most drug treatments. The…

Credit: CIAC Enantioselectivity plays an important role in the pharmacological and toxicological processes of chiral drugs. In chiral drug synthesis that uses bioorthogonal chemistry within complex biological milieu,…

Credit: Penelope Hancock In a step toward better control of the mosquitoes that transmit malaria, researchers have mapped the patterns of insecticide resistance in Anopheles gambiae mosquitoes across Africa. The new study,…

In this articale, we have described a new practical cyclocondensation synthesis for a series of triazolopyrido pyrimidine and pyrido pyrimido triazine from 2-amino-3-cyano-4.6-diarylpyridines. Also polyheterocyclic compounds containing…

This article by Dr. Carlos Polanco et al. is published in Current Proteomics, 2020 The life span of the Aedes aegypti mosquito ranges from two to four weeks depending on environmental conditions, during which the female lays about one…

Researchers find rogue stem cells lurking withinCredit: University of Houston For over a decade Wa Xian, research associate professor of biology and biochemistry at the University of Houston Stem Cell Center, has been perfecting…

Credit: Adapted from Nano Letters 2020, DOI: 10.1021/acs.nanolett.0c02278 Scientists are working overtime to find an effective treatment for COVID-19, the illness caused by the new coronavirus, SARS-CoV-2. Many of these efforts…

Credit: UNC School of Medicine CHAPEL HILL, NC - June 16, 2020 - Rapidly acting drugs to treat depression, anxiety, or substance abuse without side effects do not exist. Researchers led by Bryan L. Roth, MD, PhD, the Michael Hooker…

Credit: University of South Australia In a sign that designer drugs are becoming more prevalent in Australia, synthetic cathinones - commonly known as 'bath salts' - have been detected in the nation's wastewater in the largest…

New research to a study small molecule cell adhesion activator to facilitate the engraftment rate of cord blood cellsCredit: Photo Credit © 2020 Texas Heart Institute The Texas Heart Institute and 7 Hills Pharma (7 Hills) received a $1.9…

Team of UGA scientists building on previous SARS researchCredit: UGA Athens, Ga. - A team of researchers at the University of Georgia has successfully demonstrated that a set of drug-like small molecules can block the activity of a…