Pharmaceutical Chemistry

Project receives DARPA contract worth up to $33 million over 4 1/2 yearsCredit: Northwestern University A Northwestern University-led team of researchers has signed a cooperative agreement with the Defense Advanced Research…

Many people live with chronic pain, and in some cases, cannabis can provide relief. But the drug also can significantly impact memory and other cognitive functions. Now, researchers reporting in ACS' Journal of Medicinal Chemistry have…

The article by Dr. Mohammed Elimam Ahamed Mohammed is published in the journal, Current Molecular Medicine COVID-19 has had a significant impact since the pandemic was declared by WHO in 2020, with over 3 million deaths and counting,…

Variation in how animals and bacteria use heme reveals potential target for new antibioticsCredit: (Courtesy of Robert Kranz) It took an unlikely food innovation -- earth-friendly vegetarian patties, made to taste and "bleed" like…

Credit: POSTECH Cerebral aneurysms are malformations caused by abnormalities on the walls of blood vessels in the brain. When these blood vessels rupture, about 30% of the sufferers die on the spot, giving these the rightful label of…

Tests of a new antiviral that aims to prevent the deadly Marburg virus from spreading in the body show promise, according to a study led by University of Pennsylvania researchersCredit: Penn Vet Microscopy Core Facility The Marburg…

New research on organ maturation models could lead to improvements in drug developmentCredit: Image: Matti Ahlgren Determining safe yet effective drug dosages for children is an ongoing challenge for pharmaceutical companies and…

Researchers from the University of Liverpool have shown the potential of repurposing an existing and cheap drug into a long-acting injectable therapy that could be used to treat Covid-19. In a paper published in the journal Nanoscale,…

T-cell acute lymphoblastic leukemia (T-ALL) is a very aggressive type of blood cancer. It is relatively rare but still draws a lot of attention as it mostly develops in children under the age of 20. The standard treatment for T-ALL…

Credit: AstraZeneca. First published in Nigel Davies et al.; Molecular Therapy: Nucleic Acid, Volume 24, 4 June 2021, Pages 369-384, DOI: 10.1016/j.omtn.2021.03.008 under Attribution-NonCommercial-NoDerivatives 4.0 International (CC…

Bentham Science has recently launched the new volume of the book, Frontiers in Clinical Drug Research - Anti-Cancer Agents. Frontiers in Clinical Drug Research - Anti-Cancer Agents is a book series essential for pharmaceutical scientists,…

People with diseases such as rheumatoid arthritis and lupus are more likely to have heart attacks, angina, and strokes. A review of the scientific literature on the subject shows that regular exercise improves vascular function in these…

Small cell lung cancer cells exposed to synthetic analog of chili pepper compound responded better to chemotherapy A new study found that non-pungent synthetic analog of capsaicin -- the compound that makes chili peppers hot -- made small…

Scientists have made a promising step towards developing a new drug for treating acute myeloid leukaemia, a rare blood disorder. In a study published today in Nature, Cambridge researchers report a new approach to cancer treatment that…

Can insulin be administered orally by simply mixing it with a small intestine permeable cyclic peptide?Left: blood glucose levels continued to decrease from 15 to 60 minutes after administration. This decrease in blood glucose levels…

A study in cells and mice finds compound works with fewer side effects than opioids Fentanyl, oxycodone, morphine--these substances are familiar to many as a source of both pain relief and the cause of a painful epidemic of addiction and…

An international team led by a Skoltech researcher has developed a method of fabrication for biodegradable polymer microcapsules, made more efficient by turning to an unusual source of inspiration - traditional Russian dumpling, or…

Credit: WEHI, Australia Potential new antimalarial drug candidates are being developed through an extended drug-discovery collaboration between Australian medical research institute WEHI and Janssen Pharmaceutica NV. The…

Vilcek Foundation releases audiobook memoir of Dr. Jan Vilcek, narrated by Daniel K. IsaacCredit: Photo courtesy of the Vilcek Foundation. Photo by Alan Radom. New York, April 20, 2021--The Vilcek Foundation announces the…

Suppressing a gene regulator could reduce pancreatic cancer resistance to vital chemotherapeutic treatment.Credit: Yutaka Kondo Nagoya University researchers and colleagues in Japan have uncovered a molecular pathway that enhances…