Pharmaceutical Chemistry

Gene editing delivery method in mice suggests possible one shot treatment of high cholesterolCredit: Tufts University The genome editing technology CRISPR has emerged as a powerful new tool that can change the way we treat disease.…

Biological activity-based modeling could improve screening for promising drug compounds Assessing a drug compound by its activity, not simply its structure, is a new approach that could speed the search for COVID-19 therapies and reveal…

Credit: Johan Wingborg In recent years, techniques have been developed to treat diseases with what are known as oligonucleotide drugs, based on short DNA or RNA molecules. The Wallenberg Centre for Molecular and Translational…

Oak Brook, IL - The March edition of SLAS Discovery features the cover article, "Therapeutic and Vaccine Options for COVID-19: Status After 6 Months of the Disease Outbreak" by Christian Ogaugwu (Federal University Oye-Ekiti, Ekiti State,…

Rice University lab's process simplifies fluoroketone synthesisCredit: Illustration by Renee Man/@chemkitty HOUSTON - (Feb. 26, 2021) - Save your silver! It's better used for jewelry than as a catalyst for drugs. Rice University…

Bentham Science is pleased to announce the launch of a new subscription-based journal, Current Cosmetic Science. The first issue of the journal will be available online by the start of the year, 2021. The journal is edited by Dr. Syed…

Credit: 2021 Innovation Center of NanoMedicine February 26, 2021 - Kawasaki, Japan: The Innovation Center of NanoMedicine (Director General: Prof. Kazunori Kataoka, Location: Kawasaki in Japan, Abbreviation: iCONM) reported…

Scientists identify first compound to repair degenerating brain cells in paralyzing disease New compound targets neurons that initiate voluntary movement After 60 days of treatment, diseased brain cells look like healthy cells More…

Scientists develop peptides that could inactivate coronavirus COLUMBUS, Ohio - Fool the novel coronavirus once and it can't cause infection of cells, new research suggests. Scientists have developed protein fragments - called peptides -…

An analysis published in the Journal of the American Geriatrics Society indicates that while adults aged 75 years and older do not benefit from taking aspirin to prevent cardiovascular disease, many do so on a regular basis. Also,…

In Switzerland and other European countries, drug prices are regulated to ensure affordable access to drugs. In the last few years, many European countries have introduced rebate schemes for drugs. In most cases, however, the rebates…

Findings from a new Geisel-led study, published in the Journal of General Internal Medicine, reveal that there is substantial variation across different regions of the country in the intensity of fracture-associated drug (FAD) use among…

A drug that helps us to eat less could help the more than 650 million people around the world who live with obesity. One of the emerging drug candidates that interest researchers is the hormone GDF15 that, when given to rodents, lowers…

Both Asia and Africa are home to many plants that can be used for the treatment of many diseases and their medicinal properties are gaining interest in western societies. Medicinal plants from Asia and Africa are used for their healing…

Credit: Zhe Sang PITTSBURGH, Feb. 15, 2021 - By capitalizing on a convergence of chemical, biological and artificial intelligence advances, University of Pittsburgh School of Medicine scientists have developed an unusually fast and…

To ensure an effective global immunisation strategy against COVID-19, vaccines need to be produced at scale, priced affordably, and allocated globally so that they are available where needed, and successfully rolled out. Peer-reviewed /…

Macrophages that boost tumor growthCredit: UNIVERSITY OF BARCELONA Tumor cells are able to avoid the attack of the immune system through several mechanisms. For instance, these can secrete factors that turn macrophages -cells in the…

Research from the University of Kent, Goethe-University in Frankfurt am Main, and the Philipps-University in Marburg has provided crucial insights into the biological composition of SARS-CoV-2, the cause of COVID-19, revealing vital clues…

Credit: © 2021 KAUST; Heno Hwang Loading a cancer immunotherapy drug onto a metal organic framework improves both its delivery and its sustained release for treating leukemia. Furthermore, coating the drug-loaded framework with a…

Scientists have found catalysts that improve an important industrial reaction and make it more eco-friendlyCredit: Kazuaki Ishihara Nagoya University scientists have developed a chemical reaction that produces high yields of a compound…