Phase I NK510-PD-1 combination shows preliminary safety in nine lung cancer patients
A nine-patient phase I trial found that TIGIT-disrupted NK510 could be combined with PD-1 blockade without observed dose-limiting toxicities in ...
Tag: PD-1 blockade
KRAS-mutant tumors flood themselves with adenosine to blind immune cells
Researchers report that oncogenic KRAS reprograms adenosine metabolism through NT5E upregulation and ADA suppression, creating an immunosuppressive tumor microenvironment that ...
Blocking FGFR Signaling Supercharges Immunotherapy in Hard-to-Treat Colorectal Cancer
New research shows that inhibiting the FGFR signaling pathway reduces T cell exhaustion and repolarizes macrophages, significantly enhancing PD-1 blockade ...
Macrophage Signal WNT5A Drives Lung Cancer Scarring That Blocks Immunotherapy
A new study reveals how SPP1-positive macrophages secrete WNT5A to activate matrix-remodeling fibroblasts in lung adenocarcinoma, building a stiff tumor ...
Experimental Drug Tolinapant Boosts Immunotherapy Response in Advanced Solid Tumors
A phase I trial found that the IAP antagonist tolinapant combined with pembrolizumab was well tolerated and produced a 33 ...
Old Antibiotic Clofoctol Rewires the Immune System to Boost Glioblastoma Immunotherapy
Researchers report that the antibiotic clofoctol redistributes CD8-positive T cells from the bone marrow and enhances their tumor-killing activity, substantially ...
Liquid Biopsy Guides First-of-Its-Kind Immunotherapy Win in Relapsed Lymphoma
A high tumor mutational burden detected by liquid biopsy guided nivolumab treatment that produced a durable complete remission in a ...
Scientists Discover a Molecular Switch That Helps Breast Cancer Hide From Immunotherapy
New research shows that the stromal protein RAMP3 drives macrophage-mediated immune exclusion in breast cancer and undermines PD-1 blockade, suggesting ...
Staphylococcal Protein Reprograms Liver Tumor Macrophages to Boost Immunotherapy
A bacterial protein called LukS-PV reprograms immunosuppressive macrophages in liver cancer by targeting the human C5aR1 receptor, restoring CD8-positive T-cell ...
RNA Editing Enzyme ADAR1 Emerges as Key Switch That Turns Cold Bladder Tumors Hot
Researchers found that inhibiting the RNA editing enzyme ADAR1 reprograms the immunosuppressive tumor microenvironment of bladder cancer and sensitizes it ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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