Liquid Biopsy Guides First-of-Its-Kind Immunotherapy Win in Relapsed Lymphoma
A high tumor mutational burden detected by liquid biopsy guided nivolumab treatment that produced a durable complete remission in a ...
Tag: PD-1 blockade
Scientists Discover a Molecular Switch That Helps Breast Cancer Hide From Immunotherapy
New research shows that the stromal protein RAMP3 drives macrophage-mediated immune exclusion in breast cancer and undermines PD-1 blockade, suggesting ...
Staphylococcal Protein Reprograms Liver Tumor Macrophages to Boost Immunotherapy
A bacterial protein called LukS-PV reprograms immunosuppressive macrophages in liver cancer by targeting the human C5aR1 receptor, restoring CD8-positive T-cell ...
RNA Editing Enzyme ADAR1 Emerges as Key Switch That Turns Cold Bladder Tumors Hot
Researchers found that inhibiting the RNA editing enzyme ADAR1 reprograms the immunosuppressive tumor microenvironment of bladder cancer and sensitizes it ...
Chemoradiotherapy May Unlock Immunotherapy in Hard-to-Treat Rectal Cancer
A new review argues that neoadjuvant chemoradiotherapy may induce immune checkpoint blockade responsiveness in mismatch repair-proficient rectal cancer, with sequential ...
Where does the immune pressure go? New framework explains immunotherapy resistance
A new Molecular Cancer review proposes immune-pressure redistribution as a unifying framework explaining why patients resist PD-1/PD-L1 blockade and how ...
Tumor Vesicles Loaded with SPP1 Rewire Fibroblasts to Shield Lung Cancer from Immunity
New research shows that lung adenocarcinoma cells package the protein SPP1 into extracellular vesicles to reprogram fibroblasts into an MMP11-positive ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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