Blood Inflammation Markers Track Gut Microbe Loss and Predict Sepsis Survival
A prospective single-center cohort study of 215 septic adults links elevated serum MCP-1, GDF-15, PCSK9, and NLRP3 to reduced fecal ...
Tag: PCSK9
Computational study ranks Andrographis diterpenoids at the PCSK9–LDLR interface
A computational study of six Andrographis paniculata diterpenoids found that andrograpanin, though not the top docking scorer, engaged the broadest ...
RNA acetylation enzyme NAT10 drives aortic valve calcification through PCSK9
A new iScience study shows that the RNA acetyltransferase NAT10 stabilizes PCSK9 mRNA through N4-acetylcytidine modification, driving the osteogenic transformation ...
Cholesterol Drug Alirocumab Shields the Heart From Alcohol Damage in Rat Study
A new GeroScience study shows that weekly alirocumab, an approved PCSK9 inhibitor, protected rats from alcohol-induced cardiac dysfunction, fibrosis, and ...
Base Editing Rewrites PCSK9 in Human Embryos Without DNA Breaks, Study Finds
Researchers delivered an adenine base editor as a protein into human embryos, achieving efficient PCSK9 editing without double-strand breaks, though ...
Three Years of Real-World Data Reveal How Well the Cholesterol Gene Silencer Inclisiran Holds Up
A three-year real-world study of 109 patients in the German Inclisiran Network finds that the twice-yearly PCSK9-silencing injection lowers LDL ...
New Lipid Nanoparticles Supercharge CRISPR Delivery of Bulky Gene-Editing RNA
Researchers at the University of Toronto engineered an ionizable lipid, LC-1, that preserves its fusogenic structure when loaded with large ...
Scientists Confront the Social Stakes of Epigenetic Editing and Environmental Health
Round table discussions at the 2024 Clinical Epigenetics International Conference exposed deep divisions among scientists over whether epigenetic editing is ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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