Patient-derived CRC-X1 cell line supports colon cancer liver-metastasis research
A patient-derived colon cancer liver-metastasis cell line, CRC-X1, was stably passaged through 59 generations, formed tumors in 60% of mouse ...
Tag: oxaliplatin
Hidden BRD4-S Protein Shields Gastric Tumors From Cell Death and Blunts Chemotherapy
A short isoform of the BRD4 protein helps gastric cancer cells resist ferroptotic cell death by sustaining glutathione production, thereby ...
Tiny RNA Molecule Reveals How Nerves Fight Back Against Chemotherapy Damage
Researchers in South Korea have shown that the microRNA miR-378f directly targets CAB39 to regulate AMPK/mTOR signaling and autophagy, revealing ...
Pomegranate-Derived Polyphenol Ellagic Acid Boosts Oxaliplatin Against Colorectal Cancer, Study Finds
New research shows the plant polyphenol ellagic acid sensitizes wild-type TP53 colorectal tumors to oxaliplatin by suppressing ATM signaling and ...
Cryo-EM Reveals How RNA Polymerase II Remodels and Stalls at Cisplatin DNA Crosslinks
Cryo-electron microscopy captures RNA polymerase II remodeling cisplatin-induced DNA interstrand crosslinks into a novel conformation that blocks the active site, ...
Three-Gene Signature Predicts Survival and Platinum Drug Response in Liver Cancer
Researchers at Sun Yat-Sen University have developed a three-gene signature based on platinum resistance biology that predicts overall survival and ...
Blood Test Steers Chemotherapy Decisions in Colon Cancer Trial
The phase 2 PEGASUS trial tested whether serial circulating tumor DNA measurements can safely guide de-escalation or escalation of adjuvant ...
Japanese Gastric Cancer Care Transformed by Immunotherapy Shift, 12-Year Data Show
A 12-year Japanese database study of 16,573 patients shows first-line nivolumab plus chemotherapy rapidly displaced cisplatin-based regimens in HER2-negative advanced ...
-
Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
-
University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
-
Bee body mass, pathogens and local climate influence heat tolerance
-
Researchers record first-ever images and data of a shark experiencing a boat strike
-
Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!