Researchers have identified the polymer overlap concentration as the critical threshold required to stabilize high drug-loaded amorphous solid dispersions by ...
Pharmacokinetic evaluations in mice demonstrate that formulated licochalcone A achieves substantial mammary tissue distribution and crosses an intact blood-brain barrier ...
Researchers developed domain-alteration chimeras that bind two cooperating proteins to suppress prostate cancer tumors in preclinical models while sparing normal ...
Preclinical experiments demonstrate that novel domain-alteration chimeras rewire oncogenic protein complexes, inhibiting prostate cancer growth while sparing healthy tissue.
A systematic review indicates that salvianolic acid B significantly reduces preclinical kidney injury markers, though substantial heterogeneity and exclusive reliance ...
A machine learning pipeline trained on 192 FDA-approved compounds predicts human oral bioavailability with an R2 of 0.766, outperforming previous ...
An AAPS Open editorial spotlights chemical engineer Lucas Attia, whose PhD work matured nanoemulsion templating for drug nanoparticle formulation and ...
A Frontiers in Aging review argues that natural triterpenoids such as celastrol, ursolic acid and ginsenosides could complement existing obesity ...
Computational screening of four halogenated quinoline derivatives identifies QNL1 and QNL3 as promising oral drug candidates against tuberculosis, E. coli, ...
A cucurbituril host–guest formulation of ticagrelor boosts solubility, doubles systemic exposure, and shifts macrophages toward an anti-inflammatory state in preclinical ...
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