Pooled case reports reveal often MRI-silent nivolumab pituitary toxicity
A pooled analysis of 45 patients from published case reports found that nivolumab-associated pituitary toxicity mainly affected the ACTH-cortisol axis, ...
Tag: nivolumab
Low-Dose Nivolumab Shows Responses in Retrospective Nepal Cancer Cohort
A retrospective Nepalese cohort of 31 patients associated 20- or 40-milligram nivolumab with responses across advanced cancers, but uncontrolled evidence ...
Nivolumab Delivers Remarkable Remission in Late Liver Metastasis Recurrence of Advanced Malignant Melanoma
A Japanese case report documents a remarkable sustained response to nivolumab in a patient whose stage III melanoma recurred as ...
When Cancer Immunotherapy Turns the Immune System Against Blood: A Rare Case of Checkpoint Inhibitor Anemia That Healed Without Steroids
A case report from Gunma University describes severe autoimmune hemolytic anemia triggered by nivolumab plus ipilimumab for melanoma that resolved ...
Dual Immunotherapy Clues Reveal How to Wake the Immune System Against Glioblastoma
Two UCLA-led studies identify T-cell infiltration as the key to effective glioblastoma immunotherapy and introduce a preclinical model that recreates ...
Sliced Tumors Keep Their Immune System Alive, Opening a New Window on Bladder Cancer Drug Testing
Researchers at Lund University have shown that precision-cut slices of bladder tumors keep their immune cells alive and functional for ...
When Cancer Immunotherapy Attacks the Pituitary: Largest Case-Based Analysis Maps Nivolumab-Induced Hypophysitis
A patient-level synthesis of 40 published cases shows that nivolumab-induced hypophysitis predominantly damages the pituitary's cortisol-regulating axis, responds well to ...
Immune Checkpoint Drugs May Trigger Nerve Damage in Patients Primed for Neuroinflammation
A large analysis of melanoma patients treated with immune checkpoint inhibitors finds that 12 percent develop significant neurotoxicity, often within ...
Early Symptoms May Predict Survival in Advanced Kidney Cancer, CheckMate 9ER Analysis Shows
A post hoc analysis of the CheckMate 9ER trial links early worsening of bone pain and sleep quality to higher ...
Statistical Rework Reveals Even Larger Survival Gain for Kidney Cancer Drug Combination
A two-stage estimation analysis of the CheckMate 9ER trial shows that removing the influence of subsequent therapy substantially enlarges the ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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