Plant Terpenes May Rewire Ion Channels Linked to Diabetes and Fibrosis
A new review in Molecular Biology Reports argues that plant-derived terpenes and terpenoids may modulate TRPV ion channels to influence ...
Tag: NF-kappaB
Hidden Metabolic Trick Lets Myeloma Cells Steal Fuel to Survive a Key Cancer Drug
New research reveals that resistant myeloma cells import putrescine through the transporter SLC45A4, activating HOXA1-driven NF-kappaB signaling with help from ...
RNA Chemical Tag Emerges as Hidden Driver of Kidney Damage in Diabetes
A new study shows that the RNA demethylase FTO stabilizes EGR1 mRNA through m6A modification, activating a STING1-driven inflammatory cascade ...
Coffee Compound Trigonelline Eases Parkinson’s Symptoms in Mice by Calming Brain Inflammation and Reshaping Gut Microbes
A new preclinical study shows that trigonelline, a coffee-derived alkaloid, reduces alpha-synuclein pathology and neuroinflammation in Parkinson's model mice while ...
Bacterial Toxin Challenge Gets a Timing Makeover in the Hunt for Brain-Saving Plant Compounds
A new review proposes a kinetics- and mechanism-informed framework for using lipopolysaccharide-induced neuroinflammation models to screen phytochemicals with greater rigour ...
A Tiny Dose of Radiation Could Stop Cancer From Spreading to the Liver
A single 2 Gy prophylactic dose of liver radiation reprograms hepatic immune cells via an SAA1–TLR2–CXCL10 signaling axis to recruit ...
Peanut Root Compound Shows Promise Against Inflammation-Driven Bile Duct Cancer
A Thai research team reports that an arachidin-rich extract from peanut hairy root cultures suppresses inflammation-driven molecular events linked to ...
CBD Rewires the Liver Transcriptome and Calms Inflammatory Cytokines in Mice
A new mouse study shows cannabidiol suppresses pro-inflammatory cytokines while driving profound, dose- and time-dependent gene expression changes in the ...
Viral Saboteur Unmasked: How EBV Silences a Key Immune Molecule to Drive Nasopharyngeal Cancer
A new review in Cancer Immunology, Immunotherapy details how EBV-encoded miR-BART4 suppresses the innate immune molecule BPIFB1/LPLUNC1, whose loss promotes ...
AI-Guided Modeling Uncovers Hidden Switches That Could Heat Up Cold Pancreatic Tumors
Researchers at Eindhoven University of Technology combined active learning with mechanistic logic-ODE models to uncover context-specific regulators of the immune-recruiting ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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