Quinoline scaffolds drive new wave of antiprotozoal drug discovery
The burden of protozoan disease is not evenly distributed across the globe, and this asymmetry shapes nearly every aspect of ...
Tag: neglected tropical diseases
Proline Analogues Expose a Metabolic Weak Spot in the Chagas Disease Parasite
Trypanosoma cruzi, the single-celled parasite behind Chagas disease, has long frustrated drug developers... One of the more striking aspects of ...
Brazil’s Silent Battle Against Barriga d’Água: Why Schistosomiasis Refuses to Disappear
A new review reveals that Brazil's schistosomiasis burden is shifting toward aging chronic patients and entrenched transmission pockets, demanding integrated ...
Community health workers in Rwanda match dermatologists at spotting podoconiosis with app and paper tools
A new study in Rwanda shows that community health workers using either a WHO mobile application or a simple clinical ...
Why Leprosy Care Comes Late in Tanzania: Stigma, Witchcraft Beliefs and Failing Clinics
A qualitative study in Tanzania traces how witchcraft beliefs, stigma and health-system failures combine to delay leprosy diagnosis and treatment.
Sandflies in Cameroon’s visceral leishmaniasis hotspot stay active all year, peaking in the dry season
A twelve-month trapping survey in Kousseri, northern Cameroon, reveals year-round sandfly activity with dry-season peaks and a surprisingly rare known ...
Triple-Drug Treatment Fails to Halt Lymphatic Filariasis in Samoa, Mosquito Surveys Reveal
A five-year study in Samoa finds that two rounds of triple-drug mass treatment failed to reduce human antigen prevalence for ...
New Diamine Compounds Show Potent Activity Against Multiple Leishmania Species
A second-generation library of N,N′-disubstituted aliphatic diamines shows potent, selective activity against multiple Leishmania species, with compounds 12a, 12m, and ...
Liver Flukes Deploy Tiny Molecular Messengers to Disarm the Host Immune System
A new review synthesizes how extracellular vesicles released by Fasciola liver flukes manipulate host immunity and could guide novel vaccines ...
Frozen or Chilled? Study Maps How Urine Storage Shapes a Key Schistosomiasis Test
A field study on Pemba Island, Tanzania, shows that freezing urine slightly reduces detection of the schistosomiasis antigen CAA near ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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