Cancer Drug in Clinical Trials May Work Through an Entirely Different Target Than Assumed
A new study finds the experimental cancer drug zavondemstat and the research compound QC6352 act mainly by blocking the enzyme ...
Tag: Nature Chemical Biology
Evolved Lantern Tool Lights Up RNA and Protein Neighbors in Living Cells
Researchers have used directed evolution to engineer Lantern into a faster enzyme capable of labeling both RNA and protein neighbors ...
Chemical Maps Expose Iron-Linked Enzyme as Hidden Guardian of Damaged DNA
A comprehensive chemogenomic map of the DNA damage response reveals that peroxiredoxin 1 safeguards cells against iron-driven oxidative DNA damage.
Macrophages move captured proteins onto their own surface during live-cell uptake
New research shows that macrophages can transfer functionally active proteins from engulfed live cells onto their own surface rather than ...
Chemists Craft a One-Handed Molecule That Disarms a Cell-Death Protein
Chemists have developed a single-enantiomer covalent inhibitor that locks the cell-death protein BAX in its inactive state and protects tissue ...
New Enzyme AvaS Builds Aminovaleramide on tRNA Using Vitamin B6 Chemistry
Researchers have identified AvaS as a pyridoxal phosphate-dependent enzyme that biosynthesizes aminovaleramide and installs the modification on tRNA, expanding the ...
Hidden Sequence Motif Reveals How Natural Enzymes Harness Unusual Redox Cofactors
Researchers have identified a conserved sequence motif that enables many natural enzymes to use noncanonical redox cofactors, expanding the known ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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