Zebrafish Reveal a Surprising Trick for Rebuilding Nerves: Letting Dendrites Go First
New research in adult zebrafish shows that transient dendritic pruning driven by repressed mTORC1 signaling is essential for efficient axonal ...
Tag: mTORC1
How a Single Glycolytic Enzyme Decides Whether Cancer Cells Grow or Senesce
A new study in Advanced Science shows that losing the glycolytic enzyme TPI1 causes DHAP to accumulate and activates a ...
Hidden Enzyme in B Cells Emerges as a Master Switch for Allergic Asthma
Deleting the Ssu72 phosphatase specifically in B cells sharply reduces IgE and IgG1 production and lung inflammation in a mouse ...
Heart Disease Genetics: Little-Known Chaperone Hero11 Emerges as Coronary Risk Gene
Genetic variants in the heat-resistant obscure chaperone protein Hero11, encoded by C19orf53, are associated with coronary artery disease risk and ...
Cellular Antenna Turned Metabolic Command Center: How Primary Cilia Reshape Health and Disease
A new review redefines the primary cilium as a dynamic sensory-metabolic hub whose disruption contributes to cardiovascular, reproductive, metabolic, cancer ...
A Single DNA Letter Tweak Rewires a Cancer Gene’s Translation and Stress Response
A common inherited variant in the DDIT4 3′ UTR controls translation efficiency of the tumor-suppressing stress-response gene, reshaping mTOR signaling, ...
Immune Cell Enzyme p38 MAPK Emerges as a Molecular Fingerprint in Rare Nerve Diseases
A new study links elevated p38 MAPK activity in immune cells to multifocal motor neuropathy severity and shows that intravenous ...
Astrocyte Enzyme PHGDH Drives Blood Vessel Repair After Stroke
New research shows that the astrocytic enzyme PHGDH supplies serine to growing brain vessels through endothelial SLC38A2 transport and mTORC1 ...
Rapamycin Nanoparticles Rejuvenate Aging Spine Discs by Silencing a Cellular Aging Switch
Rapamycin-loaded nanoliposomes inhibited mTORC1-driven senescence in rat disc cells and slowed intervertebral disc degeneration in vivo, pointing toward an injectable ...
Cellular Scissors: How the Deubiquitinase STAMBPL1 Shapes Health and Fuels Cancer
A new review details how the JAMM-family deubiquitinase STAMBPL1 maintains cellular homeostasis and, when overexpressed, drives tumor progression, metastasis, and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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