Review Challenges Classical Monocyte Differentiation and Evaluates Humanized Mouse Models
A review challenges the classical mononuclear phagocyte system model, proposing that macrophages act as mobile messengers and evaluating humanized mouse ...
Tag: monocytes
Immune gene KDM6A drives heart failure after attack, mouse study shows
A mouse and patient study finds that hematopoietic loss of the X-linked gene KDM6A worsens cardiac recovery after myocardial infarction ...
Low-oxygen conditioning of transplant recipients extends heart graft survival in mice
A mouse study finds that conditioning transplant recipients, not donors, under chronic hypoxia prolongs heart allograft survival through a HIF2-dependent ...
IFN-γ Restores Trauma-Dampened Monocytes but Fails to Prevent Ventilator-Associated Pneumonia
High-dimensional immune profiling of 104 trial participants shows interferon-gamma restored monocyte function but did not prevent ventilator-associated pneumonia, pointing instead ...
Ancient Alu Elements Emerge as Dynamic Immune Enhancers in Human Monocytes
A reanalysis of chromatin data from human monocytes shows that Alu elements gain enhancer-associated histone marks during bacterial LPS stimulation, ...
Immune Complexes of SARS-CoV-2 RNA and Nucleocapsid Drive Inflammation
A PLOS Pathogens study shows that SARS-CoV-2 RNA, nucleocapsid protein and anti-N IgG1 form immune complexes that trigger inflammatory cytokines ...
Blood tests fail to distinguish causes of aseptic knee revision surgery
A study of 156 aseptic revision knee replacements found that routine blood markers and standard synovial cell counts cannot distinguish ...
Monocytes in rheumatoid and psoriatic arthritis follow distinct inflammatory paths
A new study finds that CD14-positive monocytes from rheumatoid arthritis and psoriatic arthritis patients show distinct inflammatory, metabolic, epigenetic and ...
Scientists map the signals that turn monocytes into lipid-handling macrophages
A new study shows that PKC signalling, acting through FAK, PI3K/AKT and the transcription factors NF-κB and PPARG, drives monocytes ...
Vaccine adjuvant AS01 induces trained immunity and slows tumor growth in mice
A new study in Myeloid Cells reports that the vaccine adjuvant AS01 induces trained immunity in human monocytes and slows ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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