RPL22 Mutations May Shape Drug Sensitivity in Aggressive Endometrial Cancer
Researchers found RPL22 mutations in 42% of undifferentiated/dedifferentiated endometrial carcinoma samples and showed in cell and xenograft models that the ...
Tag: mismatch repair deficiency
Bladder Cancer Diagnosis: When Should It Trigger Lynch Syndrome Testing?
A new clinical mini-review proposes an evidence-informed framework for deciding which bladder cancer patients should be evaluated for previously unrecognized ...
Research report: Case Report: Metachronous multiple primary neoplasms in a carrier of germline MSH2 c.958dupA Lynch syndrome
A case report documents four metachronous neoplasms in one MSH2 mutation carrier over eight years, with only the endometrial cancer ...
CD4 T Cell Help Powers Immunotherapy Response in Tumors Lacking MHC-I
Mouse experiments show that CD4+ T cells license CD8+ T cells through CD40 signaling, enabling combination immunotherapy to eliminate mismatch ...
Research report: Differential MMR protein stability and heterogeneity in bladder versus non-bladder urothelial carcinomas
In a 108-patient tissue study, mismatch repair deficiency was absent from bladder urothelial carcinoma cases and stable across paired specimens, ...
Five Years Without Recurrence: Short-Course Immunotherapy Reshapes dMMR Colon Cancer Care
Long-term results from the phase 2 NICHE-2 trial show that none of 111 patients with dMMR colon cancer treated with ...
New Dataset Profiles Microsatellite Instability in Colorectal Cancers That Strike Cancer Survivors
A FAIR²-certified dataset from a single Chinese hospital documents mismatch repair and microsatellite instability status, tumor sites, histology, and comorbidities ...
Rare POLE p.T278K Mutation Drives Ultramutated Endometrial Cancer in Landmark Case
A detailed case report from China shows that a rare non-hotspot POLE p.T278K mutation, alongside dual MSH6 frameshift variants and ...
Two Approved Companion Diagnostics Validate Pembrolizumab Eligibility Across dMMR/MSI-H Tumors
Bridging studies confirm that the Ventana MMR RxDx Panel and FoundationOne CDx reliably identify dMMR/MSI-H tumor patients likely to respond ...
Hypermutation Gives Weak Cancer Drivers a Head Start, Study Finds
Mathematical modelling shows that elevated mutation rates and mutational biases, rather than altered selection, can explain why weak atypical KRAS ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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