A Simple Blood Index May Shape Risk of Dementia, Metabolic Disease and Sleep Problems
A phenome-wide Mendelian randomization study of over 265,000 people suggests the CALLY index, a composite of CRP, albumin and lymphocyte ...
Tag: Mendelian randomization
CASP9 Emerges as a Double-Edged Gene in Kidney Cancer, Study Finds
A multi-omics study identifies CASP9 as a genetically protective but stage-dependent prognostic factor in clear cell renal cell carcinoma, linking ...
Where Fat Settles May Shape Polycystic Ovary Syndrome Risk, Global Study Finds
A multi-modal study integrating global burden data, Mendelian randomization, and machine learning finds genetic and clinical evidence that regional fat ...
RNA Splicing Errors in Drug Transporter Genes May Predict Cancer Survival Across 33 Tumor Types
A sweeping multi-omics study links alternative splicing of ABC transporter genes to survival across 33 cancer types and confirms causal ...
Gut Microbes May Shape Ovarian Disease Risk, Genetic Study Finds
A Mendelian randomization study links gut bacterial genera to seven ovarian-related diseases, suggesting bidirectional causality along the gut-ovary axis.
Massive Genetic Study Uncovers 18 DNA Regions Linked to Pancreatic Cancer Risk
A cross-population meta-analysis of over 1.4 million people identified 18 genetic loci for pancreatic cancer, including four new ones, along ...
ADAM8/17 Emerges as a Promising Drug Target in Intrahepatic Cholangiocarcinoma
A new study identifies the enzymes ADAM8 and ADAM17 as causally linked drivers of intrahepatic cholangiocarcinoma and demonstrates that a ...
New Genetic Factor Analysis Method Reveals Hidden Shared Roots of Disease
A new Bayesian method called genetic factor analysis decomposes genome-wide association data into shared pleiotropic factors, revealing the hidden genetic ...
Childhood Obesity Leaves Lasting Fingerprints on Blood Proteins Across Life
A new Nature Communications study shows that childhood adiposity reshapes the human plasma proteome in ways that persist into adulthood ...
MRI, Genes and Single-Cell Data Point to Vulnerable Brain Regions in ALS
By integrating MRI, brain-wide gene expression and single-cell sequencing, researchers have identified MOBP and ZNHIT3 as candidate genes underlying region-specific ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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