Single-Cell Atlas Reveals How Sonic Hedgehog Medulloblastoma Comes Back
Medulloblastoma is the most common malignant brain tumor in children, and the sonic hedgehog (SHH) subtype accounts for roughly one-third ...
Tag: medulloblastoma
Childhood Brain Tumor Study Exposes KDM2B as a Treatable Weak Spot in High-Risk Medulloblastoma
A comprehensive epigenetic analysis led by St. Jude and KiTZ identified the chromatin regulator KDM2B as an essential, selective dependency ...
Cerebellum’s Whispering Brush Cells May Hold Timing Clues for Schizophrenia
A new scoping review in Translational Psychiatry surveys five years of research on the cerebellar unipolar brush cell, a rare ...
Fat-Filled Droplets Power the Deadliest Childhood Brain Tumours
New research shows that high-risk Group 3 and Group 4 medulloblastoma cells accumulate cholesterol ester-rich lipid droplets that support energy ...
Radiation Turns Childhood Brain Tumor Cells Senescent—and Senolytic Drugs Can Kill Them
New research shows that gamma irradiation drives p53 wild-type medulloblastoma cells into a senescent state that senolytic drugs such as ...
Childhood Brain Tumor Study Uncovers KDM2B as a Selective Epigenetic Vulnerability
A comprehensive epigenomic map of medulloblastoma reveals that the chromatin regulator KDM2B sustains the highest-risk tumor subgroups by locking neuronal ...
Pediatric Neurosurgeon Michael Taylor Receives Inaugural Texans Conquer Cancer Award for Brain Tumor Research
Texas Children's pediatric neurosurgeon Dr. Michael Taylor has been named one of the first four recipients of CPRIT's Texans Conquer ...
Engineered Natural Killer Cells Show Potent Activity Against Glioblastoma in New Study
Researchers engineered fratricide-resistant CD70-targeting natural killer cells that potently killed patient-derived glioblastoma cells in laboratory and animal models.
Massive Single-Cell Map of Childhood Brain Tumor Reveals Immune Signal That Predicts Survival
A single-cell and spatial transcriptomic atlas of medulloblastoma maps developmental hierarchies and identifies the PPIA-BSG tumor-immune signaling axis as an ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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