Chlorine Position Decides Which Oxadiazole Molecules Kill Breast Cancer Cells
Chemists have designed nine 1,3,4-oxadiazole derivatives that inhibit breast cancer cells in vitro, with the lead compound R3 showing an ...
Tag: medicinal chemistry
Symmetry Rules: How One Shape of a Nitro-Schiff Base Outshines Its Rivals
A computational study shows that the symmetrical EE isomer of a nitro-substituted bis-Schiff base is the most stable form, exhibits ...
Plant Compounds Called Flavonoids Could Become Next-Generation Leukemia Drugs
A new computational Perspective argues that flavonoids, exemplified by the soy isoflavone daidzein, are a largely untapped and rationally designable ...
Hybrid Pyrimidine–Oxadiazole Molecules Show Striking Potency Against Cancer Cells
Chemists have fused pyrimidine and 1,3,4-oxadiazole rings into a new family of hybrid molecules, and the best member kills breast, ...
Computational Models Point to Linezolid-Like Antibiotics That Outbind the Original
Researchers used QSAR modelling and molecular docking to identify pyridine-based oxazolidinone derivatives that bind the bacterial ribosome more tightly than ...
One-Pot Mannich Chemistry Turns Piperazine Into a Drug Discovery Powerhouse
A sweeping review of 2020-2025 literature shows that Mannich-type multicomponent reactions have become the fastest, greenest route to piperazine-based molecules ...
Lanthanum Nanorods Deliver New Drug Candidate That Kills Parasitic Worms
Egyptian researchers used lanthanum hydroxide nanorods to synthesize a triazolopyrimidine compound that kills Trichinella spiralis larvae and adult worms at ...
Black Cumin Compound Derivative Shows Promise Against Diabetic Kidney Disease
A new disubstituted thymoquinone derivative designated TQ13 inhibited TLR2 and TLR4 signaling and protected kidney function in diabetic rats, offering ...
Engineered Enzymes Forge Antibiotic Scaffolds from Simple Alkenes
Scientists at Caltech and the University of Pittsburgh have engineered haemproteins to convert simple unactivated alkenes directly into chiral oxazolidinone ...
From Molecular Glues to AI: The Technologies Reshaping Drug Discovery
A 58-article special issue of Molecular Diversity shows how synthetic chemistry, protein degraders, natural products, and AI-driven screening are converging ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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