DNA Repair Enzyme Shields Mouse Tissues from Chemotherapy-Induced Breaks
Inactivating the DNA repair enzyme polymerase kappa in mice heightened the DNA double-strand breaks caused by the chemotherapy drug mitomycin ...
Tag: knock-in mice
Approved Drugs Dissolve Mutant Polymerase Aggregates and Restore Motor Function in Mice
Two already approved drugs, diltiazem and sulbactam, dissolved mutant POLGA aggregates and restored mitochondrial DNA replication and motor function in ...
New mouse tool targets microvascular endothelial cells in muscle and fat
Scientists have created a CTRP9-CreERT2 knock-in mouse line whose tamoxifen-inducible reporter selectively labels microvascular endothelial cells in heart, skeletal muscle, ...
One Gene’s Slow Rise May Explain How Primate Brains Grew Big and Folded
A new Nature Genetics study shows that gradual evolutionary increases in the expression of the gene CCNB1IP1 helped drive the ...
Proteasome Inhibition Eases Proteinuria in Mice With Faulty Kidney Filtration Genes
Blocking the proteasome reduces protein leakage in the urine of mice carrying dysfunctional Lmx1b LIM domains, pointing to a new ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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