Lactate tag on RPA1 drives DNA repair and breast cancer chemoresistance
Researchers report that lactate-driven lactylation of the DNA repair protein RPA1 at lysine 167, catalyzed by KAT8 after ATM phosphorylation, ...
Tag: KAT8
Lactate Tags a Tumor Suppressor and Fuels Liver Cancer Growth
Researchers report that lactate-driven lactylation of the tumor suppressor OVOL2 at lysine 3, catalyzed by KAT8, weakens its nuclear function ...
Phase-Separation Discovery Reveals How a Key Gene-Regulating Complex Assembles Itself
New research shows that the scaffolding protein KANSL1 forms liquid-like condensates that assemble the NSL chromatin complex and drive the ...
Hidden Protein Modification Lets Pancreatic Cancer Evade Ferroptosis and Resist Chemotherapy
A new Nature Cancer study reveals how hypoxia-induced lactylation of MMSDH triggers ACSL4 degradation through propionylation, helping pancreatic cancer evade ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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