Host Genomics Could Reshape How Doctors Diagnose Immune Disorders and Treat Infections
More than 30 experts outline how patients' germline genomes could improve infectious disease care, from detecting rare immune disorders early ...
Tag: inborn errors of immunity
Sirolimus and Antibody Replacement Fall Short of Proof in Rare Immune Syndrome Review
A systematic review of 79 records found no prospective trials of sirolimus or immunoglobulin replacement therapy in APDS, with evidence ...
FAS and FASL Blood Tests Fall Short as Diagnostic Biomarkers for Autoimmune Lymphoproliferative Syndrome
A new study finds that whole-blood FAS and FASL mRNA expression cannot reliably distinguish autoimmune lymphoproliferative syndrome from immune thrombocytopenia, ...
Targeted Biologics Show Promise for Severe Allergy in Rare Genetic Immune Disorders
A new systematic review of 172 patients finds that dupilumab, omalizumab, and JAK inhibitors can meaningfully control severe atopic disease ...
New Dashboard Brings Protein Structure Into the Hunt for Disease-Causing Gene Variants
Researchers have developed ProtSAVI, an R-based dashboard that combines protein structure analysis with ACMG/AMP criteria to reclassify variants of uncertain ...
Living in Lockdown by Choice: Immune Disorder Patients Show Hidden Depression and Anxiety
A German cross-sectional study of 143 patients with inborn errors of immunity finds that infection-related self-isolation is strongly associated with ...
Two Transplants, One Immune Rebuild: Letermovir Shields a Rare Immunodeficiency Case
A case report in Annals of Hematology details how sequential stem cell and liver transplantation, supported by letermovir CMV prophylaxis ...
Predicting Effects of Human Missense Variants Using Functional Evidence
A new artificial-intelligence-based approach could make one of genetics’ most difficult problems substantially easier: determining which single-letter changes in DNA ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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