Anatomy-Guided Nanomedicines Aim to Deliver Cancer Drugs Where They Matter Most
A new review proposes an anatomy-guided framework in which the bladder, prostate and kidney each demand distinct nanomedicine designs to ...
Tag: Immunotherapy
Two Approved Companion Diagnostics Validate Pembrolizumab Eligibility Across dMMR/MSI-H Tumors
Bridging studies confirm that the Ventana MMR RxDx Panel and FoundationOne CDx reliably identify dMMR/MSI-H tumor patients likely to respond ...
Sliced Tumors Keep Their Immune System Alive, Opening a New Window on Bladder Cancer Drug Testing
Researchers at Lund University have shown that precision-cut slices of bladder tumors keep their immune cells alive and functional for ...
Eczema Drug Dupilumab Shows Promise Against Stubborn IgG4-Related Disease
A new case series and literature review suggest the interleukin-4 and interleukin-13 blocker dupilumab may bring relief to patients with ...
Ribosome-Building Enzyme DIMT1 Emerges as a Pan-Cancer Biomarker and Gastric Cancer Drug Target
A comprehensive pan-cancer study identifies the ribosome biogenesis enzyme DIMT1 as a prognostic and immune-associated biomarker whose depletion suppresses gastric ...
Conformation-Selective PI3Kδ Inhibitor Roginolisib Shows Safety and Survival Signals in First-in-Human Cancer Trial
A first-in-human trial shows that the conformation-selective PI3Kδ inhibitor roginolisib is well tolerated in advanced cancers and is associated with ...
Clinical Trials Drive a New Era in Prostate Cancer Detection and Treatment
The Alliance for Clinical Trials in Oncology is marking Prostate Cancer Awareness Month by highlighting a portfolio of clinical trials ...
One Gene, Two Proteins: Why CFH Cancer Biomarker Studies May Be Measuring the Wrong Molecule
A new commentary in BMC Cancer warns that pan-cancer studies treating CFH as a single cancer biomarker have been measuring ...
Grid-Shaped Radiation Beats Conventional Beams in Boosting CAR T Therapy for Brain Lymphoma
A rat study shows that spatially fractionated minibeam radiation, unlike conventional radiotherapy, preserves the efficacy of CD19-directed CAR T cells ...
RNA Cap Modification Emerges as a Switch That Governs Tumor Response to Radiotherapy
A new study shows that the RNA cap-modifying enzyme PCIF1 drives tumor growth and radioresistance, and that removing its m6Am ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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