MSIPep prioritizes tumor peptides in leukemia and solid-tumor datasets
MSIPep combines immunopeptidomics, transcriptomics and deep learning to identify and computationally prioritize candidate tumor peptides in leukemia and solid-tumor datasets.
Tag: immunopeptidomics
Calreticulin Is Not the MHC Class I Gatekeeper Immunology Textbooks Claimed
A new study finds that calreticulin, long considered an essential chaperone for MHC class I antigen presentation, is functionally expendable ...
T Cells That Recognize the Heart: Mapping the Antigens Behind Cardiac Disease
A new review in Nature Reviews Cardiology lays out a framework for defining heart-specific T cell responses and the cardiac ...
Mass Spectrometry Uncovers Hidden Bacterial Targets of Tularemia Immunity
Using mass spectrometry-based immunopeptidomics, researchers identified 57 MHC-II peptides from 23 Francisella tularensis proteins and pinpointed ten immunogenic CD4 T ...
Cancer’s Hidden Proteome: Thousands of Dark Proteins Emerge as Drug Targets
A landmark Perspective in Nature Reviews Cancer argues that the cancer dark proteome — thousands of uncharacterized proteins from non-canonical ...
Ancient Viral Fossils in Tumors Reveal Targets That Drive Anti-Metastatic Immunity in Breast Cancer
New research shows that T cell responses against endogenous retroviral peptides, particularly murine leukemia virus fragments, are critical for checkpoint ...
AI Steps In to Rescue Personalized Neoantigen Cancer Vaccines From Costly Guesswork
A new review details how artificial intelligence is being woven into every stage of personalized neoantigen cancer vaccine development, from ...
Proximity-guided graph learning reveals tumour-associated proximity antigens
The concept of a proximity antigen sits at an important intersection of tumour immunology, spatial biology, and machine learning, and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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