Immune Protein GBP7 Turns Traitor, Helping Herpes Simplex Virus Translate Its Way to Infection
A new PLOS Pathogens study shows that the interferon-induced GTPase GBP7 unexpectedly promotes HSV-1 infection by activating the translation factor ...
Tag: immune response modulation
Trojan Horse Inhibitors Slip Through Gasdermin Pores to Shut Down Pyroptosis
New research shows that gasdermin D pores formed during pyroptosis can admit selectively designed caspase inhibitors, allowing the inflammatory cell ...
Zebrafish Help Scientists Solve a 30-Year Mystery of an Inflammation Signal That Both Alarms and Shields
MSK scientists identified the long-unknown enzyme behind the inflammatory signal 5-oxoETE and discovered that the pathway also protects healthy cells ...
Plant Compounds Target Host Immune Signaling to Fight Influenza A Virus
A new review in MicrobiologyOpen details how plant-derived phytochemicals modulate TLR, RIG-I, MAPK, and NF-κB signaling to combat influenza A ...
Sunlight, Seasons and Survival: Vitamin D Fails to Explain Timing Effects in Immunotherapy
A large UK pan-cancer study finds no consistent link between the season of checkpoint inhibitor initiation and overall survival, despite ...
RIPK2 Inhibitor GSK583 Curbss H1N1 Flu Replication and Tames Lung Inflammation in Mouse Study
A new study in Virology Journal shows that the RIPK2 inhibitor GSK583 suppresses H1N1 influenza replication and inflammatory signaling in ...
Ancient Viral Fossils Decoded: New Tool untangles the Human Genome’s Endogenous Retroviruses
A new phylogeny-guided computational tool called ERVmancer resolves the mapping ambiguity of human endogenous retroviruses, revealing locus-level expression patterns in ...
Aging Stem Cells Lose Their Healing Power, Landmark Review Finds
A systematic review of 45 studies finds that senescent mesenchymal stem cells consistently lose proliferative and migratory capacity and may ...
Liver Macrophages Carrying Apolipoprotein E Act as a Molecular Brake That Drives T Cell Exhaustion and Preserves Transplant Tolerance
A specialized APOE-producing Kupffer cell population in transplanted livers restrains rejection by driving attacking CD8-positive tissue-resident memory T cells into ...
Mogrosides regulate tumor metabolism and immune response, revealing dual anticancer mechanism
The monk fruit, a small green gourd native to the mountainous forests of Guangxi province in southern China, has been ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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