Macrophage Enzyme MMP14 Helps Tumors Build an Immune Shield, Study Finds
A new study shows that the macrophage enzyme MMP14 generates soluble semaphorin 4D, a signal that builds an immunosuppressive tumor ...
Tag: immune exclusion
Tousled-Like Kinases TLK1 and TLK2 Emerge as Pan-Cancer Drivers of Genomic Instability and Immune Evasion
A pan-cancer analysis of 33 tumor types reveals that the DNA-repair kinases TLK1 and TLK2 drive genomic instability and shape ...
Fibroblast Shield: How Osteosarcoma Builds a Wall Against the Immune System
A new review maps how cancer-associated fibroblasts exclude immune cells from osteosarcoma tumors and outlines the therapeutic strategies that could ...
Liver Cancer Gene GNG4 Found to Build Walls That Keep Immune Cells Out of Tumors
New research links the gene GNG4 in malignant liver cells to tumor immune exclusion and reduced CD8-positive T cell infiltration ...
New Spatial Index Measures the Immune Barrier That Shields Tumours From Attack
Researchers have introduced the Spatial Immune Barrier Index, a spatial transcriptomics measure that quantifies the suppressive barrier holding immune cells ...
RNA Chemical Tag ac4C Reveals Fibroblast Signal That Drives Colorectal Cancer Aggression
A comprehensive profiling study links the ac4C RNA modification to aggressive colorectal cancer and identifies CERCAM in cancer-associated fibroblasts as ...
Tumor Vesicles Loaded with SPP1 Rewire Fibroblasts to Shield Lung Cancer from Immunity
New research shows that lung adenocarcinoma cells package the protein SPP1 into extracellular vesicles to reprogram fibroblasts into an MMP11-positive ...
AI maps collagen highways and myeloid roadblocks that trap T cells in pancreatic cancer
A new computational platform reveals how collagen architecture and myeloid cells cooperate to trap therapeutic T cells in pancreatic tumors, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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