Interactions between circular RNAs (circRNAs) and the Hippo pathway in cancer
A 2026 review identifies multiple mechanisms through which circular RNAs regulate Hippo signaling and summarizes evidence linking them to cancer ...
Tag: Hippo pathway
Eye Cancer’s Hidden Weakness: CRISPR Screens Expose p300 as a Lifeline for GNAQ-Mutant Tumors
CRISPR-based synthetic lethal screening has identified the acetyltransferases p300 and CBP as essential chromatin partners for YAP-driven transcription in GNAQ-mutant ...
AI-Designed Pan-TEAD Inhibitor ISM6331 to Show First Human Data at ESMO 2026
Insilico Medicine will present the first clinical data for its AI-designed pan-TEAD inhibitor ISM6331 in a Rapid Oral session at ...
How fruit fly tumors reveal ancient pathways that drive human RAS cancers
A new Drosophila cancer atlas called ART-D maps ten genetically defined Ras-driven tumor models through three stages of malignancy and ...
TEAD transcription factors emerge as a new frontier in cancer therapy
A new review in Molecular Cancer details how the TEAD family of transcription factors drives cancer, the drugs now targeting ...
Lost Tumour Suppressor on Chromosome 6q Drives Deadly Childhood Brain Cancer and Reveals a Drug Target
New research shows that loss of the tumour suppressor LATS1 on chromosome 6q drives Hippo pathway dysregulation in ultra-high-risk PFA ...
Master Switch Discovered That Decides How Adult Spinal Cord Stem Cells Choose Their Fate
New research reveals that the Hippo pathway effector YAP1 acts as a master switch controlling whether adult spinal cord stem ...
Kidney Cancer Paper Retracted After Editors Flag Overlapping Figures
The Journal of Experimental & Clinical Cancer Research has retracted a 2019 study claiming that NR1B2 suppresses kidney renal clear ...
Sudden Stress Surges, Not Chronic Load, Push Cancer Cells Toward Invasive Growth, MRI-Tracking Sensors Reveal
A new MRI-readable nanoparticle sensor shows that abrupt surges of mechanical stress, rather than cumulative load, trigger epithelial–mesenchymal transition in ...
Engineered vaccinia virus GC001 shows potent tumour killing and clean safety profile
A thymidine kinase-deleted oncolytic vaccinia virus engineered to silence STRIP1 shows broad anti-tumour activity, ROS-Hippo pathway synergy and a clean ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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