Scientists Uncover a Sugar-Burning Switch That Drives Liver Scarring
A new Nature Communications study shows that the ubiquitin ligase PRPF19 drives hepatic stellate cell activation and liver fibrosis by ...
Tag: HIF-1α
Low Oxygen Inside Tumors Fuels Cervical Cancer Growth and Cisplatin Resistance, Study Finds
Researchers at Chongqing Medical University report that hypoxia silences the tumor suppressor CCNDBP1 in cervical cancer, activating a USP11–Nrf2 antioxidant ...
Cellular Bridges Under Low Oxygen: How ER-Mitochondria Contacts Drive Gastric Injury
A new study reveals how hypoxia-driven ER-mitochondria contact sites and the membrane-rupturing protein NINJ1 conspire to destroy the gastric lining ...
Sugar Metabolism Emerges as a Master Switch Controlling Bone Rebuilding
A new review argues that glycolysis acts as a signaling hub in bone remodeling, with glycolytic enzymes and metabolites such ...
Plant-Powered Hydrogel Halts Cell Death to Heal Diabetic Wounds
A bio-inspired hydrogel combining baicalein, glycyrrhizic acid nanofibers, gelatin and zinc ions suppresses ferroptosis in endothelial cells and closed 96 ...
Scientists Reveal How the PARK7–PINK1 Protein Axis Controls Stem Cell Reprogramming
A new study shows that the PARK7–PINK1 protein axis, known for its links to Parkinson's disease, regulates stem cell reprogramming ...
AI-guided screen finds drug-candidate molecules that shield cells from oxygen starvation
A deep-learning-guided virtual screen identified four molecules that block the HIF-1α/VHL interaction, including the approved myeloma drug ixazomib, which protected ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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