Ciclesonide May Ease Sorafenib Resistance in Liver Cancer, Study Suggests
A CRISPR screening-informed five-gene signature identifies liver cancer patients with poor sorafenib response, and ciclesonide emerges as a candidate drug ...
Tag: hepatocellular carcinoma
Immune structures inside liver tumours linked to better immunotherapy outcomes
A retrospective study of 45 hepatocellular carcinoma patients found that intratumoral tertiary lymphoid structures were associated with disease control and ...
Muscle Loss on CT Scans Linked to Poorer Survival in Liver Cancer Patients After TACE
A meta-analysis of sixteen studies found that CT-defined sarcopenia was significantly associated with poorer overall survival, progression-free survival and tumor ...
TRIM29 drives liver cancer growth by tagging DAPK3 for destruction
TRIM29 promotes hepatocellular carcinoma growth by tagging the DAPK3 protein for proteasomal degradation, according to a new Cell Death Discovery ...
Gene Signature Tied to Folate Metabolism Predicts Liver Cancer Survival Unevenly
A 20-gene folate metabolism signature predicted hepatocellular carcinoma survival in some cohorts but failed in another, and the glutathione synthetase ...
DCAF13 Drives Liver Cancer Growth by Tagging RCAN1.4 for Destruction
A new study reports that the ubiquitin ligase substrate receptor DCAF13 promotes hepatocellular carcinoma progression by targeting RCAN1.4 for degradation ...
Six-gene T cell signature predicts survival in hepatocellular carcinoma
A six-gene T cell-derived signature built from single-cell transcriptomics stratified hepatocellular carcinoma patients by survival risk in two independent cohorts.
EGFR-IL-8 Feedback Loop Drives Lenvatinib Resistance in Liver Cancer Cells
A new cell-culture study reports that an EGFR-IL-8 signaling loop between liver cancer cells and macrophages sustains lenvatinib resistance in ...
Aflatoxins: The Silent Food Contaminant Behind Hundreds of Thousands of Deaths
A new narrative review finds aflatoxins contaminate a quarter of global agricultural commodities, contribute to up to 28.2 percent of ...
Peritumoral MRI Metrics Outperform Tumor Measures for Predicting Liver Cancer Invasion
A prospective study of 70 patients found that diffusion MRI metrics measured just outside liver tumors predicted microvascular invasion better ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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