Hypoxia-Driven Mitochondrial Enzyme Helps Pancreatic Cancer Evade Ferroptosis and Resist Gemcitabine
A new study links tumor hypoxia to ferroptosis suppression via SQOR-mediated coenzyme Q reduction, offering a potential strategy to overcome ...
Tag: gemcitabine resistance
Scientists Link a DNA-Building Enzyme to Fat Rewiring and Chemotherapy Failure in Pancreatic Cancer
A new study identifies RRM2 as a gene that connects nucleotide metabolism and SREBP1/FASN-driven lipid remodeling to gemcitabine resistance in ...
Enzyme USP16 Drives Pancreatic Cancer Growth and Gemcitabine Resistance Through a Glycolytic Switch
Researchers have identified a METTL3/IGF2BP1-USP16-FUBP1-LDHA regulatory axis that drives glycolysis-dependent progression and gemcitabine resistance in pancreatic ductal adenocarcinoma, highlighting USP16 ...
Hidden Protein Modification Lets Pancreatic Cancer Evade Ferroptosis and Resist Chemotherapy
A new Nature Cancer study reveals how hypoxia-induced lactylation of MMSDH triggers ACSL4 degradation through propionylation, helping pancreatic cancer evade ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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