How Well Do We Actually Measure Lymphatic Function in Lymphedema Animal Models?
A new mini-review of 70 lymphedema animal studies finds that the most accessible measurements capture late-stage tissue damage rather than ...
Tag: fibrosis
MiR-145 emerges as a driver and biomarker of the fibrotic tumor microenvironment
A new study identifies miR-145 as a driver and biomarker of the fibrotic tumor microenvironment, linking NOTCH signaling, promoter hypomethylation, ...
Diabetic Retinopathy Rewritten as a Stage-by-Stage Signaling Map
Diabetic retinopathy has long been treated in clinics as a disease of leaky blood vessels, but a new review argues ...
Potential role of CTHRC1 in renal fibrosis
Deep inside every chronically failing kidney, a quiet molecular drama unfolds. Scar tissue slowly strangles the delicate architecture of the ...
Oral bacterium Fusobacterium nucleatum and endometriosis: what the evidence really shows
A new systematic review finds that evidence linking the oral bacterium Fusobacterium nucleatum to endometriosis is biologically plausible but conflicting, ...
Fibroblast collagen signal drives gut scarring and cancer in inflammatory bowel disease
A single-nuclei study reveals how CXCL14+ fibroblasts and SPP1+ macrophages form a collagen IV-driven feedback loop that promotes fibrosis and ...
Rutin Disrupts hnRNP L Condensates to Rewire Fibrotic Metabolism in Pulmonary Fibrosis
A new study in Frontiers in Pharmacology suggests that the natural flavonoid rutin binds the splicing factor hnRNP L, interferes ...
Frozen Shoulder Study Points to Scar Tissue Remodeling, Not Cell-Death Programs
A three-cohort transcriptomic reanalysis finds extracellular-matrix remodeling as the most reproducible molecular signature of frozen shoulder, while pyroptosis, ferroptosis, and ...
Fibrosis Signal BMP4 Drains Kidney Cells’ Mitochondrial Power in Diabetic Disease
New research shows that the pro-fibrotic signal BMP4 drives mitochondrial dysfunction in kidney mesangial cells by suppressing Parkin, a key ...
Hypertensive Stress Rewires Immune Cell Signals in a Common Heart Failure Syndrome Independent of Obesity
A new study shows that hypertensive stress rewires cardiac macrophage signaling, impairing metabolic support for heart muscle cells while driving ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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