TIMP2 Protein Levels and Gene Variants Trace Ageing and Neurodegeneration in Parkinson’s Disease
New research shows that cerebrospinal fluid TIMP2 levels rise with age and track neurodegeneration in Parkinson's disease, while TIMP2 gene ...
Tag: extracellular matrix
Epigenetic Switch That Shields Cartilage From Osteoarthritis Is Revealed
A new study reveals that the epigenetic enzyme DOT1L protects cartilage in osteoarthritis by boosting ITCH expression, which in turn ...
Hidden messengers: matrix-bound vesicles rewrite the rules of tissue signalling
A new review argues that matrix-bound extracellular vesicles retained within the extracellular matrix form a distinct, tissue-specific signalling population with ...
Veins Take the Lead: Landmark Study Reveals How Human Arteries and Veins Rebuild After Devastating Leg Trauma
A prospective Finnish study of 40 trauma patients shows that intimal hyperplasia develops within days of severe leg injury and ...
Sex Shapes How the Brain’s Inhibitory Scaffolds Build Up During Early Development
A new study in rats shows that perineuronal nets in the developing hippocampus fluctuate rather than grow steadily, with females ...
Fragment-Growing Strategy Targets Elusive S1′ Pocket to Unlock Selective MMP-9 Cancer Inhibitors
Researchers in Hyderabad report an in silico fragment-based pipeline that grows small-molecule hits into the non-conserved S1′ pocket of MMP-9, ...
Scientists map B7-H3 across tumour stroma, blood vessels and immune cells
A molecule once treated as a relatively obscure feature of cancer biology is moving toward the centre of the immuno-oncology ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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