TWAS sign errors reach 33% in complex-trait analyses
A Nature Genetics analysis estimated that TWAS assigns the wrong effect direction to 23% of plasma-protein associations and 33% of ...
Tag: eQTL
A Genetic Variant Shapes Insight—and Predicts How Well Schizophrenia Drugs Work
A new study traces a complete pathway from a SOX2-OT genetic variant through impaired insight to antipsychotic treatment response in ...
Hidden in inhibitory neurons: cell-type genetics reveals KCNIP2 as a candidate epilepsy drug target
A cell-type-resolved genetic screen shows that KCNIP2, a potassium-channel accessory protein, emerges as a protective candidate epilepsy drug target only ...
Massive RNA Dataset Uncovers Hidden Genetic Switches Behind Gene Expression
A large-scale analysis of TOPMed RNA sequencing data shows that most genes are controlled by multiple independent regulatory switches that ...
Massive single-nucleus atlas reveals how genetic risk for brain disease acts cell by cell
A single-nucleus atlas of 5.6 million brain cells from 1,384 donors maps cell-type-specific genetic regulation underlying Alzheimer's disease, schizophrenia and ...
Gene Variant MCTP2 Tied to Better Recovery of Negative Symptoms in Schizophrenia
A genome-wide association study in Han Chinese patients links a variant in the synaptic gene MCTP2 to greater improvement of ...
Genetic Framework Flags Safety Risks for Inflammatory Bowel Disease Drug Targets
A new genetics-based framework systematically flags potential safety risks for inflammatory bowel disease drug targets before broad clinical exposure.
Sheep Gene ZNF280B Emerges as a Master Switch for Muscle Growth and Meat Yield
An integrated genomic study of 420 Hu sheep has identified the gene ZNF280B as a key regulator of muscle growth ...
Genetic Switches for DNA Methylation Mapped Across the Colon Cancer Genome
A genome-wide study of 250 colon cancer patients has mapped nearly 50 million genetic associations with DNA methylation at single-base ...
T-Cell Activation State Reshapes Asthma Genetics and Points to New Drug Targets
A large genetic analysis shows that asthma-linked gene regulation in CD4+ T cells changes with activation state, exposing dozens of ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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