EP300 Degradation and AKT Inhibition Slow Osteosarcoma in Preclinical Models
A PROTAC that degrades EP300 combined with AKT inhibition slowed tumor growth and extended survival in patient-derived osteosarcoma mouse models, ...
Tag: drug synergy
Lichen Compound Usnic Acid Supercharges a Key Antifungal Drug in Lab Tests
A new in vitro study finds that the lichen-derived compound usnic acid dramatically enhances posaconazole against drug-resistant fungi through ROS ...
Spirulina pigment dismantles a key shield that blocks breast cancer drug response
A new cell study shows that C-phycocyanin can strip away Mcl-1-driven resistance and make the BH3-mimetic ABT-737 far more lethal ...
Machine Learning Predicts Antibacterial Drug Synergy Without Data Leakage
Researchers developed HALO, a machine-learning framework that predicts antibacterial drug synergy from multi-level bioactivity features while exposing how data leakage ...
Cold-Start Benchmark Exposes Limits of Drug Synergy Models
A new benchmark reveals that drug synergy prediction models often rely on memorizing historical data rather than learning generalizable pharmacological ...
Massive Proteomics Dataset Powers a Virtual Cell Model for Drug Discovery
Researchers have built ProteinTalks, an AI virtual cell model trained on more than 38 million time-resolved protein measurements from perturbed ...
Bortezomib Triggers ROS-Driven Mitochondrial Cell Death and Blocks SKP2 Signaling in Skin T-Cell Lymphoma
New research shows the proteasome inhibitor bortezomib kills cutaneous T-cell lymphoma cells through ROS-dependent mitochondrial apoptosis while suppressing the SKP2-p21/p27 ...
Metabolic Enzyme ME1 Emerges as Key to Unlocking Progestin Therapy in Endometrial Cancer
Japanese researchers found that the metabolic enzyme ME1 predicts poor outcomes in endometrioid endometrial carcinoma and that inhibiting it restores ...
Drug Combinations Show Broad Synergy Against Alpha, Beta, and Gamma Herpesviruses
Researchers report that combining host-directed and direct-acting antivirals yields synergistic inhibition across alpha, beta, and gamma herpesviruses in cell culture ...
ATR Inhibitors Supercharge Bladder Cancer Chemotherapy in Patient-Derived Organoids
Dutch researchers have shown that combining the bladder chemotherapy drug mitomycin C with ATR kinase inhibitors eradicates patient-derived non-muscle invasive ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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