Trivalent Antiviral Conjugates Trap Influenza Viruses by Cross-Linking Them Together
A programmable multivalent antiviral conjugate platform shows that attaching three copies of a neuraminidase inhibitor to an Fc fragment cross-links ...
Tag: drug development
Alzheimer’s May Begin Outside the Brain: How Amyloid-Beta Travels and Where the Body Clears It
A new review in Frontiers in Aging maps the full trafficking cascade of brain-derived amyloid-beta, arguing that Alzheimer's disease arises ...
Quality by Design: The Blueprint for Faster, Safer Pandemic Drug Development
A new mini review argues that Quality by Design and Analytical Quality by Design could serve as a Pandemic-Ready Development ...
New AI Framework Maps Drug Sensitivity Down to Individual Cells in Bulk Tumor Samples
A new two-step machine-learning framework called CLIMB and CLIFF computationally deconvolves bulk RNA-seq and drug sensitivity data into cell-type and ...
Inside the UC Davis Testing Center Putting Lab-Grown Organoids and AI Models to the Real-World Test
The UC Davis NAMs Testing Center offers an independent, fit-for-purpose evaluation model for organoids, microphysiological systems and computational tools as ...
RAGE: The Diabetes Signaling Hub That Could Be Blocked Without Breaking the Brain
A new review positions the AGE–RAGE axis as a self-amplifying inflammatory hub driving diabetic complications, while warning that therapies must ...
Human Brain Tissue Reveals a Cortex Built on Different Rules Than Rodents
A new collection of studies using live human cortical tissue shows that human neurons and circuits follow distinct structural, physiological, ...
AI and the Digital Exhaust: How Everyday Data Could Transform Huntington’s Disease Drug Development
A new review argues that AI-driven passive monitoring of everyday digital data, from smartphone keystrokes to home radar sensors, could ...
Organ-on-Chip Meets Digital Twin: Systematic Review Maps the Future of Drug Development
A new systematic review of 123 studies shows that pairing organ-on-chip devices with digital twin computational models is rapidly maturing ...
Children Are Being Left Behind as Antifungal Resistance Gathers Pace, Global Pediatric Group Warns
A new International Pediatric Association analysis reveals that none of five novel antifungal drugs in late-stage development has pediatric efficacy ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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