NAT10 enzyme adds ketone-derived tag to histones to speed DNA replication
A new study reports that the enzyme NAT10 catalyzes histone β-hydroxybutyrylation, a modification that accelerates replication fork speed and reduces ...
Tag: DNA Replication
CDK1 acts as a sensitive regulator of embryonic muscle growth in goats
A study of goat embryos identifies CDK1 as a hub gene whose moderate expression promotes muscle satellite cell proliferation, while ...
Cohesin reorganizes stressed DNA replication sites to protect genome stability
An experimental cell study finds that cohesin rapidly reorganizes stressed DNA replication sites and suppresses an error-prone restart pathway, helping ...
ORC1: The Replication Gatekeeper Linking Genome Stability to Cancer
A new review in the Journal of Translational Medicine consolidates how the replication-initiation protein ORC1 safeguards genome stability and why ...
Fungal enzyme RTT109 proves essential for inheriting silenced chromatin
A new study in Neurospora crassa shows that the replication-linked histone acetyltransferase RTT109, acting independently of its known product H3K56 ...
Tousled-Like Kinases TLK1 and TLK2 Emerge as Pan-Cancer Drivers of Genomic Instability and Immune Evasion
A pan-cancer analysis of 33 tumor types reveals that the DNA-repair kinases TLK1 and TLK2 drive genomic instability and shape ...
How replication stress shapes cancer evolution and opens new doors for therapy
A comprehensive new review explains how replication stress drives cancer genome evolution and why the pathways cells use to survive ...
Unveiling the Invisible: Innovative Technique Exposes ‘Hyperaccessible’ Regions in Newly Replicated DNA
In a groundbreaking study published in the journal “Cell,” researchers from the Gladstone Institutes in San Francisco have unveiled transformative ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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