SADRP: A structurally aware multi-modal framework for drug response prediction
SADRP combines drug topology, chemical-bond information, gene expression and DNA methylation to predict drug sensitivity across cancer cell lines.
Tag: DNA Methylation
AML epigenetic therapies face network-driven resistance, review finds
A comprehensive review finds that AML cells commonly overcome epigenetic drugs through compensatory chromatin and transcriptional adaptation, favoring biomarker-selected combinations ...
Goonch Catfish Mitogenome Resolves Close Phylogeny, Flags Preliminary DNA Modifications
A single-individual study assembled the goonch catfish mitogenome, resolved B. bagarius as sister to B. yarrelli and identified unvalidated candidate ...
Review finds DNA methylation promising, but not ready for ovarian cancer screening
A 2026 review found encouraging diagnostic results for DNA methylation biomarkers in ovarian cancer but concluded that prospective evidence at ...
Review maps epigenetic control of PI3K/AKT signaling in liver cancer
A 2026 review finds that epigenetic changes sustain PI3K/AKT signaling in hepatocellular carcinoma, while experimental evidence indicates activated signaling can ...
Chemical Tags on an Estrogen Receptor Gene May Help Time Puberty in Sheep
A new study links declining methylation of the ESR2 promoter to rising gene expression in sheep ovaries as puberty begins, ...
Hidden Epigenetic Switches in Clogged Neck Arteries Reveal How Plaques Turn Deadly
A targeted epigenomic study of advanced carotid plaques reveals coordinated DNA hypomethylation of microRNA regulatory regions linked to plaque instability, ...
Scientists Map the Earliest Steps of Polycomb Gene Silencing in Human Embryos
A Nature Genetics study shows that the histone mark H2Aub laid down by PRC1 guides the reestablishment of Polycomb repression, ...
Body Clock, Gut Microbes and DNA Methylation Converge in Depression Study
A pilot multi-omics study links disrupted sleep timing, specific gut microbial signatures, and altered DNA methylation at neural-related genes in ...
Blood-based DNA methylation patterns track breast cancer response to chemotherapy
A new study links methylation changes in the KDM5 gene family and cofactors, measured in blood before and after neoadjuvant ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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