Designed proteins enable enantioselective artificial photocatalysts
Generative protein design and directed evolution produced artificial metalloenzymes that support highly enantioselective light-driven reactions with synthetic metal photocatalysts.
Tag: directed evolution
Lab Evolution’s Short Reach: E. coli Experiments Sample Less Than Half of Possible Amino Acid Swaps
A new analysis of roughly 25,000 amino acid substitutions from evolved E. coli shows that adaptive laboratory evolution samples less ...
Bacterial Enzyme Breakthrough Paves the Way for Greener Drugs and Food Ingredients
Researchers at ITQB NOVA have characterised the first bacterial galactose oxidase and engineered it into a biocatalyst up to 1800 ...
Mutations Give RNA Droplets Their Own Genes, Vacuoles and Movement
Researchers have shown that RNA droplets trap their own DNA templates, and that even low rates of mutation produce stable ...
Shotgun genetic engineering lets mammalian cells stumble onto new metabolic pathways
A Nature Biotechnology commentary highlights how shotgun genetic engineering, which tests vast random combinations of genes in mammalian cells, enabled ...
Heat-proof sugar enzyme gets a power boost through two tiny mutations
Crystal structures of an engineered hyperthermophilic sugar dehydrogenase reveal how two mutations relieve a steric barrier and boost calcium uptake ...
Engineered AAV Capsid Reaches the Outer Retina Through a Simple Eye Injection
Researchers used directed evolution to create AAV5-AlyT, an adeno-associated virus variant that delivers genes efficiently to photoreceptors after minimally invasive ...
Synthetic Plant Immune Receptors Designed on Computers and Evolved in Living Plants
Researchers are combining computational de novo protein design with directed evolution in plants to create synthetic immune receptors that can ...
PCR-Only Protein Engineering Platform Skips Bacteria and Builds Better Biosensors in a Day
A new method called MIDAS assembles and screens hundreds of protein variants directly in mammalian cells without any microbial cloning ...
AI Language Model Rescues Human Drug Transporter Mutations a Computer Deemed Impossible
Researchers used a protein language model and an epistatic rescue algorithm to computationally humanize a bacterial peptide transporter, paving the ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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