Preclinical natural products target ferroptosis defenses in liver cancer
A focused preclinical review finds that natural products can suppress NRF2-linked antioxidant defenses in hepatocellular carcinoma while protecting non-malignant liver ...
Tag: DHODH
Ferroptosis framework maps how iron-driven cell death could be pushed or blocked for precision drugs
A new Perspective proposes a unified pharmacological-toxicological framework treating ferroptosis, mitochondrial stress and redox imbalance as one axis governing both ...
Famed brain cancer drug turns out to hit a metabolic enzyme, not its intended target
A comprehensive chemical biology study shows that the celebrated KDM4 inhibitor QC6352 and its clinical analog zavondemstat kill glioblastoma stem ...
Cancer Drug in Clinical Trials May Work Through an Entirely Different Target Than Assumed
A new study finds the experimental cancer drug zavondemstat and the research compound QC6352 act mainly by blocking the enzyme ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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