Enzyme Duo Revealed as Hidden Driver of Ovarian Cancer Growth
Researchers have discovered that the deubiquitinase USP12 stabilizes the Rab GTPase-activating protein TBC1D22A, activating PI3K-AKT-mTOR signaling and driving ovarian cancer ...
Tag: deubiquitinase
Enzyme USP16 Drives Pancreatic Cancer Growth and Gemcitabine Resistance Through a Glycolytic Switch
Researchers have identified a METTL3/IGF2BP1-USP16-FUBP1-LDHA regulatory axis that drives glycolysis-dependent progression and gemcitabine resistance in pancreatic ductal adenocarcinoma, highlighting USP16 ...
Hidden Molecular Switch Links H. pylori Infection to Aggressive Gastric Cancer
A new study reveals how the ONECUT2-YOD1-STAT3-PD-L1 signaling axis drives malignant progression and immune evasion in H. pylori-associated gastric cancer.
Scientists Uncover Hidden Feedback Loop That Drives Colon Cancer Spread
A newly mapped SFRP2–Snai1–USP11 feedback loop stabilizes a key metastasis protein and activates PI3K/AKT/mTOR signalling, revealing fresh targets against colon ...
Cellular Scissors: How the Deubiquitinase STAMBPL1 Shapes Health and Fuels Cancer
A new review details how the JAMM-family deubiquitinase STAMBPL1 maintains cellular homeostasis and, when overexpressed, drives tumor progression, metastasis, and ...
Targeting the Ubiquitin Machinery to Rewire KRAS-Driven Cancers
A new review argues that deubiquitinase enzymes within the ubiquitin-proteasome system offer promising therapeutic angles against KRAS-driven cancers that resist ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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